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VIMIZIM
Elosulfase Alfa
$1625.00
5mg · 5 vial
BrandBranded medicine· By BioMarin
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FDA boxed warningHypersensitivity reactions including anaphylaxis and risk of acute respiratory complications
Patients treated with enzyme replacement therapies have experienced life-threatening hypersensitivity reactions, including anaphylaxis. Anaphylaxis has occurred during the early course of enzyme replacement therapy and after extended duration of therapy.
Initiate VIMIZIM in a healthcare setting with appropriate medical monitoring and support measures, including access to cardiopulmonary resuscitation equipment. If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue VIMIZIM and immediately initiate appropriate medical treatment, including use of epinephrine. Inform patients of the symptoms of life-threatening hypersensitivity reactions, including anaphylaxis and to seek immediate medical care should symptoms occur.
Patients with acute respiratory illness may be at risk of serious acute exacerbation of their respiratory compromise due to hypersensitivity reactions and require additional monitoring.
If a severe hypersensitivity reaction (anaphylaxis) occurs, discontinue VIMIZIM and immediately initiate appropriate medical treatment, including use of epinephrine.
About VIMIZIM
Overview
VIMIZIM contains elosulfase alfa, an enzyme made using recombinant DNA technology. It is used to treat mucopolysaccharidosis type IVA (MPS IVA), also called Morquio A syndrome. It works by supplying an enzyme that is missing or has reduced activity in this condition, helping cells break down substances called glycosaminoglycans that would otherwise build up.
What it treats
Mucopolysaccharidosis type IVA (MPS IVA), also known as Morquio A syndrome.
Safety information
Side effects
Common side effects include fever, vomiting, headache, nausea, abdominal pain, chills and tiredness. Serious risks include hypersensitivity reactions, including anaphylaxis (a severe allergic reaction), acute breathing complications, and compression of the spinal cord, including in the neck. Seek urgent medical help for a severe allergic reaction or breathing difficulty, and contact a doctor promptly if spinal cord compression is suspected. Tell your doctor before an infusion if you have an illness with fever or a respiratory illness. These may increase the risk of life-threatening complications from a hypersensitivity reaction. Your doctor may consider delaying the infusion.
FDA boxed warning
Hypersensitivity reactions including anaphylaxis and risk of acute respiratory complications
Patients treated with enzyme replacement therapies have experienced life-threatening hypersensitivity reactions, including anaphylaxis. Anaphylaxis has occurred during the early course of enzyme replacement therapy and after extended duration of therapy.
Initiate VIMIZIM in a healthcare setting with appropriate medical monitoring and support measures, including access to cardiopulmonary resuscitation equipment. If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue VIMIZIM and immediately initiate appropriate medical treatment, including use of epinephrine. Inform patients of the symptoms of life-threatening hypersensitivity reactions, including anaphylaxis and to seek immediate medical care should symptoms occur.
Patients with acute respiratory illness may be at risk of serious acute exacerbation of their respiratory compromise due to hypersensitivity reactions and require additional monitoring.
If a severe hypersensitivity reaction (anaphylaxis) occurs, discontinue VIMIZIM and immediately initiate appropriate medical treatment, including use of epinephrine.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
The label lists no contraindications to Vimizim. Patients with an acute illness involving fever or breathing problems may be at higher risk of life-threatening complications from hypersensitivity reactions. The treating clinician should carefully assess the patient’s condition before administration and consider delaying the infusion.
Using VIMIZIM
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label VIMIZIM (ELOSULFASE ALFA) INJECTION, SOLUTION, CONCENTRATE [BIOMARIN PHARMACEUTICAL INC.] (DailyMed, retrieved 19 September 2026).
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