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Strensiq
Asfotase Alfa
$22790.00
18mg · 12 vial
BrandBranded medicine· By Alexion Pharmaceuticals
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FDA boxed warningHypersensitivity reactions including anaphylaxis
Patients treated with enzyme replacement therapies have experienced life-threatening hypersensitivity reactions, including anaphylaxis. Anaphylaxis has occurred during the early course of enzyme replacement therapy and after extended duration of therapy.
Initiate STRENSIQ under the supervision of a healthcare provider with appropriate medical monitoring and support measures. If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue STRENSIQ and immediately initiate appropriate medical treatment, including use of epinephrine. Inform patients of the symptoms of life-threatening hypersensitivity reactions, including anaphylaxis and to seek immediate medical care should symptoms occur.
About Strensiq
Overview
Strensiq contains asfotase alfa, an enzyme replacement medicine given by injection under the skin. It treats hypophosphatasia (HPP) that begins around birth, in infancy or during childhood. It replaces deficient enzyme activity, reducing the buildup of substances that interfere with bone mineralization.
What it treats
Hypophosphatasia (HPP) that begins before or around birth, in infancy, or in childhood.
Safety information
Side effects
Common side effects include injection-site reactions, changes in the fat tissue under the skin (lipodystrophy), calcium deposits outside the bones, and allergic reactions. Localised fat-tissue changes have been reported after several months of treatment. Proper injection technique and rotating injection sites help address this risk. Contact your doctor about allergic reactions or suspected immune-related effects. Calcium deposits can affect the eyes and kidneys; the label recommends eye examinations and kidney ultrasounds before treatment and periodically during treatment. Your doctor may also test for antibody formation if clinically indicated.
FDA boxed warning
Hypersensitivity reactions including anaphylaxis
Patients treated with enzyme replacement therapies have experienced life-threatening hypersensitivity reactions, including anaphylaxis. Anaphylaxis has occurred during the early course of enzyme replacement therapy and after extended duration of therapy.
Initiate STRENSIQ under the supervision of a healthcare provider with appropriate medical monitoring and support measures. If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue STRENSIQ and immediately initiate appropriate medical treatment, including use of epinephrine. Inform patients of the symptoms of life-threatening hypersensitivity reactions, including anaphylaxis and to seek immediate medical care should symptoms occur.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
The supplied FDA label lists no contraindications for Strensiq. Cautions include changes in fat tissue at injection sites (lipodystrophy), reported after several months of treatment. Proper injection technique and rotating injection sites are advised. Calcium deposits may occur in the eyes and kidneys. Eye examinations and kidney ultrasounds are recommended before treatment and periodically during treatment. Possible immune-mediated effects also require caution. Patients should be evaluated for antibody formation when clinically indicated.
Interactions
Strensiq can interfere with laboratory tests that use alkaline phosphatase (ALP), potentially causing incorrect results. Tell your doctor and laboratory staff that you are receiving Strensiq so they can discuss an alternative testing method. Blood ALP levels are expected to be elevated during treatment and may not be reliable for making clinical decisions.
Using Strensiq
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label STRENSIQ (ASFOTASE ALFA) SOLUTION [ALEXION PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).
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