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Nexviazyme
Avalglucosidase Alfa-ngpt
$2060.00
100mg · 1 syringes
BrandBranded medicine· By Genzyme
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FDA boxed warningSevere hypersensitivity reactions, infusion-associated reactions, and risk of acute cardiorespiratory failure in susceptible patients
Hypersensitivity Reactions Including Anaphylaxis
Appropriate medical monitoring and support measures, including cardiopulmonary resuscitation equipment, should be readily available. If a severe hypersensitivity reaction occurs, discontinue NEXVIAZYME immediately and initiate appropriate medical treatment.
Infusion-Associated Reactions (IARs)
If severe IARs occur, consider immediate discontinuation and initiation of appropriate medical treatment.
Risk of Acute Cardiorespiratory Failure in Susceptible Patients
Patients susceptible to fluid volume overload, or those with acute underlying respiratory illness or compromised cardiac or respiratory function, may be at risk of serious exacerbation of their cardiac or respiratory status during NEXVIAZYME infusion.
About Nexviazyme
Overview
Nexviazyme contains avalglucosidase alfa-ngpt, an enzyme replacement treatment. It is used to treat late-onset Pompe disease in adults and children aged 1 year and older. It supplies an enzyme that is lacking in Pompe disease, helping break down glycogen that builds up inside cells.
What it treats
Late-onset Pompe disease (lysosomal acid alpha-glucosidase [GAA] deficiency) in patients aged 1 year and older.
Safety information
Side effects
Common side effects of Nexviazyme include headache, tiredness, diarrhea, nausea, joint pain, dizziness, muscle pain, itching, vomiting, shortness of breath, skin redness, tingling or other unusual skin sensations, and hives. Serious side effects include allergic reactions, including anaphylaxis, and reactions associated with the infusion. Seek urgent medical help for a severe allergic reaction. Contact your doctor immediately if you develop symptoms of an allergic reaction or a reaction during or after an infusion.
FDA boxed warning
Severe hypersensitivity reactions, infusion-associated reactions, and risk of acute cardiorespiratory failure in susceptible patients
Hypersensitivity Reactions Including Anaphylaxis
Appropriate medical monitoring and support measures, including cardiopulmonary resuscitation equipment, should be readily available. If a severe hypersensitivity reaction occurs, discontinue NEXVIAZYME immediately and initiate appropriate medical treatment.
Infusion-Associated Reactions (IARs)
If severe IARs occur, consider immediate discontinuation and initiation of appropriate medical treatment.
Risk of Acute Cardiorespiratory Failure in Susceptible Patients
Patients susceptible to fluid volume overload, or those with acute underlying respiratory illness or compromised cardiac or respiratory function, may be at risk of serious exacerbation of their cardiac or respiratory status during NEXVIAZYME infusion.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
The supplied FDA label lists no contraindications for Nexviazyme. It refers to boxed warnings, but their details are not included in this extract, so specific conditions requiring caution cannot be summarised here.
Using Nexviazyme
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label NEXVIAZYME (AVALGLUCOSIDASE ALFA-NGPT) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [GENZYME CORPORATION] (DailyMed, retrieved 19 September 2026).
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