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Lamzede
Velmanase alfa
$1920.00
10mg · 1 vial
BrandBranded medicine· By Chiesi
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FDA boxed warningSevere hypersensitivity reactions
Hypersensitivity Reactions Including Anaphylaxis
cardiopulmonary resuscitation equipment
, should be readily available during LAMZEDE administration. If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs,
discontinue
LAMZEDE immediately and
initiate
appropriate medical treatment. In patients with severe hypersensitivity reaction, a desensitization procedure to LAMZEDE may be considered
Appropriate medical support measures, including
, should be readily available. If a severe hypersensitivity reaction occurs,
appropriate medical treatment.
About Lamzede
Overview
Lamzede contains velmanase alfa-tycv, a laboratory-made version of the human enzyme alpha-mannosidase. It is used in adults and children to treat the effects of alpha-mannosidosis outside the central nervous system. It works by supplying this enzyme to help break down mannose-containing sugars that build up inside cells when enzyme activity is reduced.
What it treats
Treatment of manifestations of alpha-mannosidosis outside the central nervous system in adults and children.
Safety information
Side effects
Common side effects include allergic reactions, including anaphylaxis, nose and throat inflammation, fever, headache and joint pain. Anaphylaxis is a serious allergic reaction that requires immediate medical attention. Reactions associated with the infusion can also be severe. If a severe infusion reaction occurs, treatment must be stopped and appropriate medical care given. Lamzede may harm an unborn baby. Contact your doctor if you become pregnant during treatment. If you can become pregnant, use effective contraception during treatment and for 14 days after the last dose if treatment is stopped.
FDA boxed warning
Severe hypersensitivity reactions
Hypersensitivity Reactions Including Anaphylaxis
cardiopulmonary resuscitation equipment
, should be readily available during LAMZEDE administration. If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs,
discontinue
LAMZEDE immediately and
initiate
appropriate medical treatment. In patients with severe hypersensitivity reaction, a desensitization procedure to LAMZEDE may be considered
Appropriate medical support measures, including
, should be readily available. If a severe hypersensitivity reaction occurs,
appropriate medical treatment.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
The label lists no contraindications to Lamzede. However, severe infusion-associated reactions require stopping Lamzede and starting appropriate medical treatment. Lamzede may harm an unborn baby. Females who could become pregnant should use effective contraception during treatment and for 14 days after the last dose if treatment is discontinued.
Using Lamzede
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label LAMZEDE (VELMANASE ALFA-TYCV) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [CHIESI USA, INC.] (DailyMed, retrieved 19 September 2026).
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