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Kanuma
Sebelipase Alfa
$14435.00
2mg/ml · 1 vial
BrandBranded medicine· By Alexion Pharmaceuticals
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FDA boxed warningHypersensitivity reactions including anaphylaxis
Patients treated with enzyme replacement therapies have experienced life-threatening hypersensitivity reactions, including anaphylaxis. Anaphylaxis has occurred during the early course of enzyme replacement therapy and after extended duration of therapy.
Initiate KANUMA in a healthcare setting with appropriate medical monitoring and support measures, including access to cardiopulmonary resuscitation equipment. If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue KANUMA and immediately initiate appropriate medical treatment, including use of epinephrine. Inform patients of the symptoms of life-threatening hypersensitivity reactions, including anaphylaxis and to seek immediate medical care should symptoms occur.
About Kanuma
Overview
Kanuma contains sebelipase alfa, a laboratory-made version of the human lysosomal acid lipase (LAL) enzyme. It is used to treat patients diagnosed with LAL deficiency. It works inside cells to break down fats that build up when this enzyme is missing or not working properly.
What it treats
Lysosomal acid lipase (LAL) deficiency.
Safety information
Side effects
Common side effects in infants with rapidly progressing lysosomal acid lipase (LAL) deficiency beginning within the first six months of life include diarrhea, vomiting, fever, a runny or stuffy nose, anemia, cough, cold-like symptoms and hives. Common side effects in other children and adults with LAL deficiency include headache, fever, throat pain, cold-like symptoms, weakness, constipation and nausea. Contact your doctor if hives occur. Also tell your doctor if you have a known allergy to eggs or egg products that causes reactions throughout the body. The label advises weighing the risks and benefits of Kanuma treatment in people with this type of allergy.
FDA boxed warning
Hypersensitivity reactions including anaphylaxis
Patients treated with enzyme replacement therapies have experienced life-threatening hypersensitivity reactions, including anaphylaxis. Anaphylaxis has occurred during the early course of enzyme replacement therapy and after extended duration of therapy.
Initiate KANUMA in a healthcare setting with appropriate medical monitoring and support measures, including access to cardiopulmonary resuscitation equipment. If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue KANUMA and immediately initiate appropriate medical treatment, including use of epinephrine. Inform patients of the symptoms of life-threatening hypersensitivity reactions, including anaphylaxis and to seek immediate medical care should symptoms occur.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
The label lists no contraindications to Kanuma. If you have a known allergy to eggs or egg products that causes reactions affecting the whole body, your prescriber should weigh the risks and benefits before treatment.
Using Kanuma
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label KANUMA (SEBELIPASE ALFA) INJECTION, SOLUTION, CONCENTRATE [ALEXION PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).
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