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Toprol XL
Metoprolol Succinate Extended-Release
$110.00
25mg · 5 × 20 tablets · 3 months supply
BrandBranded medicine· By Astra Zeneca
$36.67 per month
Strength
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Annual cost
$396a year at this pack size
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About Toprol XL
Overview
Toprol XL is an extended-release tablet containing metoprolol succinate, a beta-blocker. It is used to treat high blood pressure, angina (chest pain), and heart failure. Lowering blood pressure reduces the risk of strokes and heart attacks, while its use in heart failure reduces the risk of cardiovascular death and hospital stays for heart failure. It works mainly by blocking beta-1 receptors in the heart, slowing the heart rate and electrical signals through the heart.
What it treats
- High blood pressure (hypertension). - Angina pectoris. - Heart failure, to reduce the risk of cardiovascular death and hospitalization for heart failure.
Safety information
Side effects
Common side effects include tiredness, dizziness, depression, shortness of breath, a slow heartbeat, low blood pressure, diarrhea, itching and rash. Contact a doctor if you develop worsening chest pain (angina), worsening heart failure, a very slow heartbeat or worsening heart block (a problem with the heart’s electrical signals). Seek emergency medical help for a suspected heart attack. Toprol XL may increase the risk of low blood sugar and hide its early warning signs. It can also worsen symptoms caused by poor blood flow in the arteries. Some medicines, including clonidine, diltiazem, verapamil and cardiac glycosides, can increase the risk of a slow heartbeat when taken with Toprol XL. Do not stop Toprol XL suddenly without medical guidance. Abrupt stopping can worsen reduced blood flow to the heart and, in people with an overactive thyroid, may trigger a thyroid storm, a serious medical emergency.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Toprol XL if you are allergic to any of its ingredients, have a very slow heart rate, second- or third-degree heart block, cardiogenic shock, decompensated heart failure, or sick sinus syndrome without a permanent pacemaker. Tell your prescriber if you have heart failure, a condition that causes narrowing of the airways (bronchospasm), low blood sugar, an overactive thyroid, poor circulation in your limbs, liver impairment, or pheochromocytoma. Beta-blockers should generally be avoided in bronchospastic disease. For pheochromocytoma, an alpha-blocker must be started first. Liver impairment requires close monitoring for side effects. Toprol XL can worsen heart failure and symptoms of poor circulation. It may increase the risk of low blood sugar and hide early warning signs. Taking it with glycosides, clonidine, diltiazem or verapamil can increase the risk of a slow heart rate. Epinephrine used to treat an allergic reaction may be less effective. Do not stop Toprol XL suddenly without your prescriber’s guidance. Sudden withdrawal can worsen reduced blood flow to the heart and may trigger a thyroid storm in people with an overactive thyroid. Tell your surgical team that you take Toprol XL; ongoing beta-blocker treatment should not routinely be stopped before surgery.
Interactions
Tell your doctor if you take medicines that reduce catecholamines, as their effects may add to those of Toprol XL. Medicines that inhibit the enzyme CYP2D6 may increase metoprolol levels in your body. If you take clonidine, discuss any plans to stop it with your doctor. Toprol XL may worsen the rebound rise in blood pressure that can occur after clonidine is stopped.
Using Toprol XL
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label TOPROL XL (METOPROLOL SUCCINATE) TABLET, EXTENDED RELEASE [MELINTA THERAPEUTICS, LLC] (DailyMed, retrieved 19 September 2026).
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