HYQVIA

Before taking this medicine

Do not use HYQVIA if you have: • A history of anaphylaxis or a severe whole-body allergic reaction to human immune globulin (IgG). • IgA deficiency with antibodies against IgA and a history of allergic reactions. • A known whole-body allergic reaction to hyaluronidase, including the recombinant human hyaluronidase in HYQVIA, or to human albumin in the hyaluronidase solution. Special caution is needed if you are over 65 or at risk of kidney problems. People with IgA deficiency and anti-IgA antibodies have a greater risk of severe allergic reactions, including anaphylaxis. HYQVIA can cause blood clots, aseptic meningitis, red blood cell breakdown and acute lung injury. Monitoring for signs of red blood cell breakdown and lung reactions is needed. Treatment should be stopped if symptoms of aseptic meningitis appear. Infusion into or around an infected area can spread the infection. Antibodies to recombinant human hyaluronidase may develop and could react with the body’s own hyaluronidase. Whether this affects fertilization in humans is unknown, and the clinical significance is unclear. HYQVIA may carry a risk of transmitting infectious agents, including viruses and the agents associated with variant Creutzfeldt-Jakob disease and, theoretically, Creutzfeldt-Jakob disease.