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Benicar Plus
Olmesartan HCTZ
$69.00
20/12.5mg · 3 × 28 tablets · 3 months supply
GenericGeneric medicine
$23.00 per month
Strength
How long a supply?
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Annual cost
$299a year at this pack size
Prescription required
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20/12.5mg
40/12.5mg
20/25mg
40/25mg
FDA boxed warningFetal toxicity
When pregnancy is detected, discontinue
olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible
- Drugs that act directly on the renin-angiotensin system (RAS) can cause injury and death to the developing fetus
- Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
About Benicar Plus
Overview
Benicar Plus is a prescription tablet containing olmesartan medoxomil and hydrochlorothiazide. It treats high blood pressure and may be used alone or with other blood pressure medicines, but it is not intended as the first treatment. Olmesartan blocks a substance that narrows blood vessels, while hydrochlorothiazide helps the kidneys remove more salt and water.
What it treats
Used to treat high blood pressure (hypertension), alone or with other blood pressure medicines. Not indicated as the initial treatment for hypertension.
Safety information
Side effects
Common side effects include nausea, raised uric acid levels in the blood, dizziness and upper respiratory infections. Serious side effects that warrant contacting a doctor include low blood pressure, especially in people with low fluid or salt levels; impaired kidney function; allergic reactions; fluid, electrolyte or metabolic imbalances; sudden short-sightedness and acute angle-closure glaucoma; systemic lupus erythematosus; and sprue-like enteropathy, an intestinal disorder. Your doctor may need to monitor kidney function and potassium levels.
FDA boxed warning
Fetal toxicity
When pregnancy is detected, discontinue
olmesartan medoxomil and hydrochlorothiazide tablets as soon as possible
- Drugs that act directly on the renin-angiotensin system (RAS) can cause injury and death to the developing fetus
- Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Benicar Plus if you are allergic to any of its ingredients, cannot produce urine (anuria), or have diabetes and are taking aliskiren. Breastfeeding is not recommended while taking this medicine. Caution is needed if you have low fluid levels, as this can increase the risk of low blood pressure. Fluid depletion should be corrected before treatment. Kidney function and potassium may need monitoring in people at risk, and patients should be monitored for signs of fluid or electrolyte imbalance. Other warnings include acute angle-closure glaucoma and a bowel condition called sprue-like enteropathy. If this bowel condition occurs and no other cause is found, the prescriber should consider stopping the medicine.
Interactions
Tell your doctor about all medicines and supplements you take, especially: • Medicines or supplements that raise potassium levels, as they may increase potassium in your blood. • Lithium, as the risk of lithium toxicity may increase. • Non-steroidal anti-inflammatory drugs (NSAIDs), which may reduce the medicine’s blood-pressure-lowering and diuretic effects and increase the risk of kidney problems. • Other medicines that act on the renin–angiotensin system, as combining them may increase the risk of kidney problems, low blood pressure and high potassium. • Colesevelam, as the timing of these medicines may need to be separated. • Diabetes medicines, which may need adjustment by your doctor. • Cholestyramine or colestipol, which may reduce absorption of hydrochlorothiazide.
Using Benicar Plus
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label OLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE (OLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE) TABLET, FILM COATED [REMEDYREPACK INC.] (DailyMed, retrieved 19 September 2026).
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