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Zoloft , Lustral

Name: Zoloft , Lustral
Brand: Pfizer
Availability: InStock

Sertraline

Prescription required

$54.00

50mg · 3 × 30 tablets · 3 months supply

Generic· By Teva

$18.00 per month

Brand or generic

Generic packs carry the same active ingredient at the same strength.

Strength

How long a supply?

1 month$18.00 a monthOne-off$18.00

3 months$18.00 a monthOne-off$54.00

6 months$18.00 a monthOne-off$108.00

Supplied from Israel

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Annual cost

$216a year at this pack size

Prescription required

Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.

50mg

100mg

FDA boxed warningSuicidal thoughts and behaviors

Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors.

Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients
Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors

Read this with the rest of the clinical information

About Zoloft , Lustral

Overview

Sertraline is a prescription medicine in a group called selective serotonin reuptake inhibitors (SSRIs). It is used to treat major depressive disorder, obsessive-compulsive disorder (OCD) and panic disorder. It also treats posttraumatic stress disorder (PTSD), social anxiety disorder and premenstrual dysphoric disorder (PMDD). It works by reducing the reuptake of serotonin by nerve cells, increasing serotonin activity in the brain.

What it treats

• Major depressive disorder (MDD) • Obsessive-compulsive disorder (OCD) • Panic disorder • Posttraumatic stress disorder (PTSD) • Social anxiety disorder • Premenstrual dysphoric disorder (PMDD)

Safety information

Side effects

Common side effects of sertraline include nausea, diarrhoea or loose stools, indigestion, reduced appetite, shaking and increased sweating. Dry mouth, trouble sleeping, sleepiness, dizziness, tiredness, agitation and constipation also occur. Sexual side effects include reduced sex drive, delayed or failed ejaculation, difficulty getting or keeping an erection, and delayed or absent orgasm. Seek immediate medical help for suicidal thoughts or behaviour, seizures, severe allergic reactions, or a severe skin reaction with blistering or peeling. Antidepressants increase the risk of suicidal thoughts and behaviour in children, adolescents and young adults. Watch for worsening depression or changes in behaviour, especially during the first few months of treatment or after dose changes, and contact the prescriber promptly. Serotonin syndrome is a potentially life-threatening reaction that can occur with sertraline alone or with other medicines that affect serotonin. Seek immediate medical help for symptoms such as agitation or confusion together with fever, heavy sweating, a fast heartbeat, muscle stiffness or twitching, shaking, poor coordination, vomiting or diarrhoea. Other serious effects that need prompt medical attention include: • Unusual bruising or bleeding, including blood in stools or black stools. Bleeding can be life-threatening, and the risk is higher with aspirin, anti-inflammatory painkillers, antiplatelet medicines or blood thinners. • Mania or hypomania, including an unusually elevated mood or increased activity. • Low blood sodium, which may cause headache, difficulty concentrating, confusion, weakness or unsteadiness. Severe cases can cause fainting, seizures or coma. Older people, people taking diuretics and those with reduced fluid levels are at greater risk. • Heart rhythm changes, including potentially life-threatening abnormal rhythms. • Angle-closure glaucoma, particularly in people with untreated narrow drainage angles in the eyes. Severe liver problems, including liver failure, and other serious reactions have been reported after sertraline entered use. Their frequency and whether sertraline caused them cannot always be established. Stopping sertraline suddenly can cause nausea, sweating, irritability, anxiety, dizziness, electric-shock sensations, shaking, sleep problems and, sometimes, seizures. Speak with the prescriber before stopping treatment.

FDA boxed warning

Suicidal thoughts and behaviors

Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients
Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors

A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.

When to call your doctor

- Seek medical attention immediately for new or worsening suicidal thoughts, or thoughts of harming yourself. - Get immediate help for agitation or confusion with fever, heavy sweating, a racing heartbeat, muscle stiffness or shaking, possible signs of serotonin syndrome. - Seek immediate care for unusual or heavy bleeding, blood in your stool, or black, tar-like stools. - Get immediate help for a seizure, fainting, or severe confusion, especially with weakness or unsteadiness. - Seek immediate care for a severe or blistering skin rash.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not take sertraline if you: • Take a monoamine oxidase inhibitor (MAOI), or stopped one within the past 14 days. This includes linezolid and intravenous methylene blue. • Take pimozide. • Are allergic to sertraline or any of the tablet’s other ingredients. Sertraline should be avoided in people with untreated narrow drainage angles in the eyes because it can trigger angle-closure glaucoma. Tell your prescriber before treatment if you have a personal or family history of bipolar disorder, mania or hypomania; a seizure disorder; or risk factors for the heart rhythm problem known as QT prolongation. Sertraline can also cause low blood sodium, particularly in older adults, people taking diuretics and people with low fluid levels. Tell your prescriber about all other medicines and supplements you take. Other medicines that affect serotonin, including some antidepressants, migraine medicines, opioids and St. John’s wort, increase the risk of potentially life-threatening serotonin syndrome. This can also occur with sertraline alone. Aspirin, NSAIDs, antiplatelet medicines and anticoagulants such as warfarin can increase bleeding risk. Children and young adults taking antidepressants have an increased risk of suicidal thoughts and behaviours. All patients should be monitored for worsening symptoms or changes in behaviour, especially during the first few months of treatment and when treatment is adjusted. If you are pregnant, discuss treatment with your prescriber. Use in the third trimester may increase the risk of persistent high blood pressure in the newborn’s lungs and withdrawal symptoms. Safety and effectiveness in children have not been established for conditions other than obsessive-compulsive disorder (OCD). Do not stop sertraline abruptly without consulting your prescriber, as withdrawal symptoms can occur.

Interactions

Sertraline must not be taken with monoamine oxidase inhibitors (MAOIs), including selegiline, phenelzine, tranylcypromine, isocarboxazid, linezolid or intravenous methylene blue, because of the risk of serotonin syndrome. It must also not be taken with pimozide because of the risk of serious heart rhythm problems. Other medicines and supplements that increase serotonin can also raise the risk of serotonin syndrome. These include other SSRIs, SNRIs, tricyclic antidepressants, triptans, opioids, lithium, buspirone, amphetamines, tryptophan and St. John’s wort. Your doctor may need to monitor you more closely, particularly when treatment starts or changes. Aspirin, clopidogrel, heparin and warfarin can increase the risk of bleeding when used with sertraline. If you take warfarin, your doctor should closely monitor your INR, a measure of blood clotting. Sertraline can increase levels of some other medicines, including phenytoin and medicines processed by the liver enzyme CYP2D6. Examples include metoprolol, nebivolol, flecainide, propafenone, atomoxetine, desipramine, dextromethorphan, perphenazine, thioridazine, tolterodine and venlafaxine. Medicines that bind strongly to blood proteins, such as warfarin, may also interact. Your doctor may need to monitor blood levels or side effects and adjust treatment. Avoid combining sertraline with other medicines known to prolong the QT interval, an electrical timing measure of the heart. These include certain antipsychotics, antibiotics and heart rhythm medicines, as well as methadone. Examples include ziprasidone, erythromycin, moxifloxacin, amiodarone and sotalol. Sertraline can cause a false-positive urine screening result for benzodiazepines, including for several days after stopping it. Tell the clinician arranging the test that you take sertraline; a confirmatory test can distinguish it from benzodiazepines.

Using Zoloft , Lustral

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label SERTRALINE TABLET, FILM COATED [REMEDYREPACK INC.] (DailyMed, retrieved 19 September 2026).

Patient information and references

Official and supporting information to read alongside advice from your prescriber or pharmacist.

Patient information leaflet (PDF)

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