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Vfend I.V.
Voriconazole
$206.00
200mg · 1 vial
BrandBranded medicine· By Anfarm Hellas
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About Vfend I.V.
Overview
Vfend I.V. contains voriconazole, a prescription azole antifungal given by intravenous infusion. It treats invasive aspergillosis, Candida bloodstream infections in patients without low neutrophil counts, and Candida infections of deep tissues or the esophagus in adults and children aged 2 years and older. It also treats serious infections caused by Scedosporium apiospermum and Fusarium species when other treatments cannot be tolerated or have not worked. It works against the fungi responsible for these infections.
What it treats
For adults and children aged 2 years and older, Vfend I.V. is used to treat: - Invasive aspergillosis. - Candida bloodstream infections in patients who are not neutropenic (do not have low neutrophil counts), and other deep-tissue Candida infections. - Esophageal candidiasis (Candida infection of the esophagus). - Serious infections caused by Scedosporium apiospermum or Fusarium species, including Fusarium solani, when other treatments cannot be tolerated or have not worked.
Safety information
Side effects
Common side effects in adults include changes in vision, fever, nausea, rash, vomiting, chills, headache, abnormal liver tests, a fast heartbeat and hallucinations. In children, common side effects also include nosebleeds, abdominal pain, diarrhoea, changes in blood pressure, cough, swelling, dizziness, constipation, shortness of breath, low platelet counts and changes in blood sugar or mineral levels. Serious side effects include liver damage, kidney problems, abnormal heart rhythms, severe skin reactions with peeling, and infusion reactions, including a severe allergic reaction called anaphylaxis. Contact a doctor immediately if a severe skin reaction or infusion reaction occurs; an infusion reaction requires the infusion to be stopped. Vision problems can include inflammation of the optic nerve or swelling where it enters the eye. Contact a doctor about changes in vision. Visual function should be monitored if treatment lasts longer than 28 days. Liver function tests are needed before and during treatment. Voriconazole can cause sensitivity to sunlight; avoid sunlight during treatment. Long-term treatment can cause fluoride-related bone damage and inflammation around bones. Contact a doctor if these problems occur. Adrenal gland problems can occur with voriconazole and corticosteroids. Monitoring is needed during and after treatment. Seek immediate medical care if signs or symptoms of Cushing’s syndrome or adrenal insufficiency develop.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not use Vfend I.V. if you have a known allergy to voriconazole or any of its other ingredients. Whether an allergy to another azole antifungal means you will also react to voriconazole is unknown. Vfend I.V. must not be used with eplerenone, ergot alkaloids such as ergotamine or dihydroergotamine, finerenone, ivabradine, lurasidone, naloxegol, pimozide, quinidine, rifabutin, sirolimus, tolvaptan, voclosporin, carbamazepine, long-acting barbiturates, rifampin or St. John’s wort. It must not be used with venetoclax when treatment is being started or gradually increased in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma, because of an increased risk of tumor lysis syndrome. Restrictions on efavirenz and ritonavir depend on their dose; some combinations are prohibited, and others should be avoided unless the prescriber considers the benefit to outweigh the risk. This is not a complete list of interactions. All medicines and herbal products must be reviewed before treatment. Serious liver reactions can occur, so liver function must be checked before and during treatment. Caution is needed in people with conditions that increase the risk of abnormal heart rhythms. Low potassium, magnesium and calcium levels must be corrected before use. Visual function should be monitored if treatment continues beyond 28 days. Avoid sunlight because voriconazole can cause photosensitivity. Infusion reactions, including anaphylaxis, require the infusion to be stopped. Severe skin reactions involving peeling require treatment to be stopped. Long-term treatment can cause fluorosis and inflammation around bones; treatment must be stopped if these occur. Patients also receiving corticosteroids need monitoring for adrenal dysfunction during and after treatment. Seek immediate medical care for signs or symptoms of Cushing’s syndrome or adrenal insufficiency. Voriconazole can harm an unborn baby. Patients who could become pregnant should use effective contraception during treatment. Safety and effectiveness have not been established in children younger than 2 years.
Interactions
Voriconazole can change the blood levels of many medicines, and other medicines can raise or lower voriconazole levels. This may increase side effects or reduce treatment effectiveness. Tell your doctor about all medicines and herbal products you use; the interactions below are not a complete list. Do not use voriconazole together with rifampin, rifabutin, carbamazepine, long-acting barbiturates such as phenobarbital, St. John’s wort, sirolimus, pimozide, quinidine, ivabradine, ergot alkaloids, naloxegol, tolvaptan, lurasidone, finerenone, eplerenone or voclosporin. Some of these combinations can cause serious adverse effects, including dangerous heart rhythm changes; others can substantially reduce voriconazole levels. Efavirenz and ritonavir need specific review by your prescriber because certain combinations are contraindicated. Ritonavir combinations that are not contraindicated should generally still be avoided unless the prescriber decides the benefit outweighs the risk. Other important interactions include: • Fluconazole and lemborexant: use together should be avoided. • Venetoclax: must not be combined with voriconazole when starting treatment or during dose escalation for chronic lymphocytic leukemia or small lymphocytic lymphoma. Use at other treatment stages, or for acute myeloid leukemia, requires prescriber-directed adjustment and safety monitoring. • Cancer medicines such as axitinib, dasatinib, ibrutinib and other listed tyrosine kinase inhibitors: use together should be avoided where possible. An alternative to glasdegib should also be considered. • Cyclosporine: blood levels can rise, increasing the risk of kidney toxicity. Blood-level monitoring and prescriber-directed adjustment are needed when voriconazole is started or stopped. • Methadone, fentanyl, alfentanil and oxycodone: effects and toxicity may increase. Monitoring may include breathing problems and, with methadone, heart rhythm changes. • Ibuprofen and diclofenac: side effects and toxicity may increase. • Phenytoin and letermovir: can lower voriconazole levels. • Contraceptives containing ethinyl estradiol and norethindrone, and certain HIV medicines: may require monitoring for voriconazole side effects or reduced effectiveness. Any treatment changes should be managed by your prescriber.
Using Vfend I.V.
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label VORICONAZOLE (VORICONAZOLE INJECTION) INJECTION [PAI HOLDINGS, LLC DBA PAI PHARMA] (DailyMed, retrieved 19 September 2026).
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