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Tzield

Name: Tzield
Brand: Sanofi
Availability: InStock

Teplizumab‑mzwv

Prescription required

$73200.00

2mg/2ml · 3 × 1 vial · 3 months supply

BrandBranded medicine· By Sanofi

$24400.00 per month

Strength

How long a supply?

1 month$24400.00 a monthOne-off$24400.00

3 months$24400.00 a monthOne-off$73200.00

6 months$24400.00 a monthOne-off$146400.00

Supplied from Israel

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Ships cold, in insulated packing

This medicine ships in insulated packing with coolant and carries its own shipping charge, shown at checkout.

Annual cost

$292800a year at this pack size

Prescription required

Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.

2mg/2ml

2mg

FDA boxed warningViral Reactivation

Serious, life-threatening cases of viral reactivation, including Epstein-Barr virus (EBV) and cytomegalovirus (CMV) reactivation have been reported with TZIELD. Patients who are immunocompromised are at increased risk. Serious cases have also been reported in adults with higher body surface area or comorbid conditions, such as adrenal insufficiency or cardiovascular disease. The majority of serious cases occurred in patients who continued TZIELD treatment despite persistent, severe lymphopenia. Severe lymphopenia may be prolonged in adults.

Test patients for active EBV and CMV infection prior to starting treatment. TZIELD is contraindicated in patients who are immunocompromised or have active viral infection (such as EBV or CMV infection). Adhere to lymphocyte count monitoring requirements and discontinuation recommendations. Monitor patients for signs and symptoms of viral reactivation following TZIELD treatment and for at least 2 months following the last infusion. If viral reactivation is suspected, discontinue TZIELD.

Read this with the rest of the clinical information

About Tzield

Overview

Tzield (teplizumab-mzwv) is a prescription monoclonal antibody supplied in a vial for intravenous use. It is used to delay the onset of Stage 3 type 1 diabetes in adults and children aged 1 year and older who have Stage 2 type 1 diabetes. It is also approved to delay the decline in the body’s own insulin production in children aged 8–17 recently diagnosed with Stage 3 type 1 diabetes; this accelerated approval is based on reduced decline in C-peptide, and continued approval may depend on confirmation of clinical benefit. It binds to CD3 on immune cells called T cells and may reduce the activity of those that attack insulin-producing cells in the pancreas.

What it treats

- Stage 2 type 1 diabetes in adults and children aged 1 year and older: to delay the onset of Stage 3 type 1 diabetes. - Recently diagnosed Stage 3 type 1 diabetes in children aged 8 to 17 years: to delay the decline in the body’s own insulin production. This use has accelerated approval based on reduced decline in C-peptide, a marker of insulin production. Continued approval may depend on confirmatory trials verifying clinical benefit.

Safety information

Side effects

Common side effects include low counts of lymphocytes and other white blood cells, including neutrophils; vomiting; rash; diarrhea; increased liver enzymes; and headache. Serious side effects include reactivation of viral infections, cytokine release syndrome, serious infections, prolonged severely low lymphocyte counts, and severe allergic reactions. Contact your doctor promptly if you develop signs or symptoms of infection during or after treatment, or suspect a serious reaction. Severe allergic reactions need prompt treatment. Your doctor will monitor your lymphocyte counts, liver enzymes and bilirubin during treatment. Treatment may need to be paused or stopped if serious reactions occur.

FDA boxed warning

Viral Reactivation

A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.

When to call your doctor

- Seek medical attention immediately if you suspect a serious infection or the return of a previous viral infection, including during the two months after your last infusion. - Seek medical attention immediately if you think you are having a severe allergic reaction.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not use Tzield if you have a weakened immune system or an active viral infection, such as Epstein–Barr virus (EBV) or cytomegalovirus (CMV). Use is not recommended if you have an active serious infection or a chronic infection. Tzield can cause cytokine release syndrome, serious infections, low lymphocyte counts and severe allergic reactions. Medicines are given before treatment to reduce the risk of cytokine release syndrome. Liver tests and lymphocyte counts must be monitored during treatment, and signs of infection monitored during and after treatment. Treatment may need to be paused or stopped if serious reactions occur. Complete all age-appropriate vaccinations before starting Tzield. Discuss vaccine timing with your healthcare professional. Tzield may harm an unborn baby. Avoid use during pregnancy and for at least 30 days before a planned pregnancy. If breastfeeding, consider pumping and discarding breast milk during treatment and for 20 days after administration.

Using Tzield

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label TZIELD (TEPLIZUMAB-MZWV) INJECTION [PROVENTION BIO, INC.] (DailyMed, retrieved 19 September 2026).

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