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Tykerb
Lapatinib (as Ditosylate Monohydrate)
$4965.00
250mg · 3 × 70 tablets · 6 months supply
BrandBranded medicine· By Sandoz
$827.50 per month
How long a supply?
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Annual cost
$8275a year at this pack size
Prescription required
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FDA boxed warningHepatotoxicity
Hepatotoxicity has been observed in clinical trials and postmarketing experience. The hepatotoxicity may be severe and deaths have been reported. Causality of the deaths is uncertain.
About Tykerb
Overview
Tykerb contains lapatinib, a kinase inhibitor. It is used with capecitabine for HER2-positive advanced or metastatic breast cancer after prior treatment with an anthracycline, a taxane and trastuzumab, when the cancer has progressed on trastuzumab. It is also used with letrozole for postmenopausal women with hormone receptor-positive, HER2-positive metastatic breast cancer when hormonal therapy is indicated. Lapatinib works by blocking enzyme activity within the EGFR and HER2 receptors involved in cancer cell growth.
What it treats
- Advanced or metastatic HER2-positive breast cancer, in combination with capecitabine, after prior treatment including an anthracycline, a taxane and trastuzumab. The cancer must have progressed on trastuzumab before starting this combination. - Hormone receptor-positive, HER2-positive metastatic breast cancer in postmenopausal women for whom hormonal therapy is indicated, in combination with letrozole.
Safety information
Side effects
Common side effects of Tykerb taken with capecitabine include diarrhea, hand-foot syndrome (a skin reaction affecting the palms and soles), nausea, rash, vomiting and fatigue. With letrozole, common side effects include diarrhea, rash, nausea and fatigue. Serious side effects that warrant contacting a doctor include reduced heart pumping function, liver injury, severe diarrhea, lung inflammation and severe skin reactions. Tykerb may also prolong the QT interval, a change in the heart’s electrical activity. Heart function and liver tests are needed before and during treatment; ECG and electrolyte monitoring may also be considered. Tykerb can harm an unborn baby. Use effective contraception and contact your doctor if you become pregnant during treatment.
FDA boxed warning
Hepatotoxicity
Hepatotoxicity has been observed in clinical trials and postmarketing experience. The hepatotoxicity may be severe and deaths have been reported. Causality of the deaths is uncertain.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Tykerb if you have a known severe allergy, including anaphylaxis, to lapatinib or any of its ingredients. Tykerb requires caution because it can reduce the heart’s pumping function, cause liver injury, severe diarrhea, lung inflammation, QT interval prolongation (a change in the heart’s electrical activity), and severe skin reactions. Heart pumping function should be checked before and during treatment. Liver function tests are required before treatment, every 4 to 6 weeks during treatment, and as clinically indicated. Severe liver impairment requires particular caution. ECG and electrolyte monitoring may also be needed. Tykerb must be stopped and not restarted if severe changes in liver function tests occur. Treatment must also be stopped for severe lung symptoms or suspected life-threatening skin reactions. Tykerb can harm an unborn baby. Pregnancy status should be checked before treatment, and effective contraception should be used. Do not breastfeed during treatment.
Interactions
Tykerb may increase the amount of certain other medicines in your body, including those processed by CYP3A4 or CYP2C8 enzymes or transported by P-glycoprotein (ABCB1). Medicines that strongly block or increase CYP3A4 activity should be avoided with Tykerb. If taking them together cannot be avoided, your prescriber may need to adjust your treatment. Ask your doctor to check any medicines you take for these interactions.
Using Tykerb
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label TYKERB (LAPATINIB) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] (DailyMed, retrieved 19 September 2026).
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