Tresiba, illustration of injection pen form (not a photo of the actual pack)

Illustrative image.

Tresiba

Insulin Degludec

Prescription required

$141.00

100iu/mL · 5 pen

BrandBranded medicine· By Novo Nordisk

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About Tresiba

Overview

Tresiba contains insulin degludec, a long-acting insulin given by injection under the skin using a prefilled pen. It is used to improve blood sugar control in adults and children aged 1 year and older with diabetes. It lowers blood sugar by helping muscle and fat cells take up glucose and reducing the amount of glucose the liver produces. It is not recommended for treating diabetic ketoacidosis.

What it treats

- Diabetes mellitus in adults and children aged 1 year and older, to improve blood sugar control. Not recommended for treating diabetic ketoacidosis.

Safety information

Side effects

Common side effects of Tresiba include low blood sugar (hypoglycemia), allergic reactions, reactions at the injection site, changes in fatty tissue under the skin (lipodystrophy), itching, rash, swelling and weight gain. Serious side effects include severe low blood sugar, severe allergic reactions including anaphylaxis, and low potassium levels. These can be life-threatening and require urgent medical attention. Fluid retention and heart failure can occur when Tresiba is used with thiazolidinediones (TZDs); contact a doctor if signs or symptoms of heart failure develop. Insulin mix-ups can cause severe low blood sugar. Check the insulin label before each injection, and never transfer Tresiba from the pen into a syringe.

When to call your doctor

• Seek immediate medical attention for severe low blood sugar, which can be life-threatening. • Seek immediate medical attention for a severe allergic reaction, including anaphylaxis.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not use Tresiba during an episode of low blood sugar (hypoglycemia), or if you are allergic to insulin degludec or any of its ingredients. Low blood sugar can be life-threatening. Closer blood glucose monitoring is needed if your insulin treatment, other medicines, meal pattern or physical activity changes, or if you have kidney or liver impairment or do not recognise the signs of low blood sugar. Changes to your insulin treatment, injection site or injection method should be made under close medical supervision, as they may cause high or low blood sugar. Check the insulin label before every injection to avoid mix-ups. Never share a Tresiba pen or needles, even if the needle is changed. Do not transfer insulin from the pen into a syringe, as this can cause an overdose and severe low blood sugar. Severe allergic reactions, including life-threatening anaphylaxis, can occur. Stop using Tresiba and seek immediate medical help if a severe allergic reaction occurs. Tresiba can also cause dangerously low potassium levels; people at risk may need potassium monitoring. Taking Tresiba with thiazolidinediones (TZDs) may cause fluid retention and heart failure and requires monitoring for signs of heart failure.

Interactions

Other diabetes medicines, ACE inhibitors, angiotensin II receptor blockers, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, salicylates, somatostatin analogues such as octreotide, and sulfonamide antibiotics may increase the risk of low blood sugar with Tresiba. Medicines that may reduce Tresiba’s blood sugar-lowering effect include certain antipsychotics, corticosteroids, danazol, diuretics, estrogens, progestogens and oral contraceptives, glucagon, isoniazid, niacin, protease inhibitors, somatropin, thyroid hormones, and medicines such as albuterol, epinephrine and terbutaline. Alcohol, beta-blockers, clonidine and lithium may either increase or decrease Tresiba’s blood sugar-lowering effect. Pentamidine may cause low blood sugar, sometimes followed by high blood sugar. Beta-blockers, clonidine, guanethidine and reserpine may make the warning signs of low blood sugar less noticeable or absent. Discuss these interactions with your doctor. More frequent blood sugar checks may be needed, and your prescriber may need to adjust your insulin treatment.

Using Tresiba

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use and how long it may be kept at room temperature afterwards. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label TRESIBA (INSULIN DEGLUDEC) INJECTION, SOLUTION [A-S MEDICATION SOLUTIONS] (DailyMed, retrieved 19 September 2026).

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