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Thalomid
Thalidomide
$1800.00
50MG · 3 × 28 capsules · 3 months supply
BrandBranded medicine· By Celgene
$600.00 per month
How long a supply?
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Annual cost
$7800a year at this pack size
Prescription required
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FDA boxed warningEmbryo-fetal toxicity and venous thromboembolism
EMBRYO -FETAL TOXICITY
If THALOMID is taken during pregnancy, it can cause severe birth defects or embryo-fetal death. THALOMID should never be used by females who are pregnant or who could be pregnant while taking the drug. Even a single dose [1 capsule (regardless of strength)] taken by a pregnant woman during her pregnancy can cause severe birth defects.
Pregnancy must be excluded before start of treatment. Prevent pregnancy thereafter by the use of two reliable methods of contraception.
THALOMID is only available through a restricted distribution program, the THALOMID REMS ® program.
VENOUS THROMBOEMBOLISM
Significant increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients with multiple myeloma receiving THALOMID with dexamethasone.
About Thalomid
Overview
Thalomid capsules contain thalidomide, a medicine that affects the immune system. It is used with dexamethasone to treat newly diagnosed multiple myeloma. It also treats moderate to severe skin symptoms of erythema nodosum leprosum (ENL) and helps prevent their recurrence, but must not be used alone for ENL when moderate to severe nerve inflammation is present. Its exact action is not fully understood, but it affects immune activity, reduces inflammation and inhibits the formation of new blood vessels.
What it treats
• Newly diagnosed multiple myeloma, in combination with dexamethasone. • Skin manifestations of moderate to severe erythema nodosum leprosum (ENL), including treatment of acute episodes and maintenance treatment to prevent and suppress recurrence. Thalomid is not used alone for ENL when moderate to severe nerve inflammation (neuritis) is present.
Safety information
Side effects
Common side effects reported in people with multiple myeloma include tiredness, weakness, constipation, nausea, reduced appetite, weight changes, swelling, low calcium levels, reduced white blood cell counts, rash or peeling skin, dry skin, dizziness, headache-like shaking (tremor), confusion, anxiety or agitation, fever, shortness of breath, muscle weakness, and nerve problems affecting sensation or movement. Blood clots were also among the most common reactions reported and are serious. In people treated for ENL, the most common side effects were drowsiness, rash and headache. Serious risks that warrant prompt medical contact include: • Birth defects if an unborn baby is exposed to thalidomide. Contact a doctor immediately if pregnancy or exposure during pregnancy occurs. • Blood clots in veins or arteries. Heart attacks and strokes have been observed when Thalomid is used with dexamethasone. • Peripheral nerve damage. Contact your doctor if you develop changes in sensation or movement. • Severe skin reactions or serious allergic reactions, including angioedema and anaphylaxis. • Low white blood cell or platelet counts. • A slow heartbeat, possible fainting, or a drop in blood pressure when standing. • Seizures and tumor lysis syndrome. • Increased HIV viral load in people with HIV. An increased risk of death was observed in people with multiple myeloma when pembrolizumab was added to dexamethasone and a thalidomide analogue. Thalomid can cause drowsiness. Avoid situations where this could be dangerous and do not take other medicines that cause drowsiness. To reduce dizziness when getting up from lying down, sit upright for a few minutes before standing.
FDA boxed warning
Embryo-fetal toxicity and venous thromboembolism
EMBRYO -FETAL TOXICITY
If THALOMID is taken during pregnancy, it can cause severe birth defects or embryo-fetal death. THALOMID should never be used by females who are pregnant or who could be pregnant while taking the drug. Even a single dose [1 capsule (regardless of strength)] taken by a pregnant woman during her pregnancy can cause severe birth defects.
Pregnancy must be excluded before start of treatment. Prevent pregnancy thereafter by the use of two reliable methods of contraception.
THALOMID is only available through a restricted distribution program, the THALOMID REMS ® program.
VENOUS THROMBOEMBOLISM
Significant increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) in patients with multiple myeloma receiving THALOMID with dexamethasone.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Thalomid if you are pregnant or have a known allergy to thalidomide or any of its ingredients. Do not breastfeed during treatment. Thalomid can cause drowsiness. Avoid situations where drowsiness could be dangerous, and do not take other medicines that cause drowsiness. It can also cause dizziness and a drop in blood pressure when standing. After lying down, sit upright for a few minutes before standing. Careful monitoring is needed for nerve damage, low white blood cell or platelet counts, a slow heartbeat or fainting, and seizures in people with a seizure history or other risk factors. People with HIV need viral-load monitoring because levels may increase. People at risk of tumour lysis syndrome, including those with a large tumour burden before treatment, need monitoring and precautions. Heart disease caused by reduced blood flow, including heart attacks, and strokes have been observed when Thalomid is used with dexamethasone. Increased deaths have been observed in people with multiple myeloma when pembrolizumab was added to dexamethasone and a thalidomide analogue. Treatment must be stopped for severe skin reactions or serious allergic reactions, including angioedema or anaphylaxis. Symptoms of treatment-related nerve damage may also require treatment to be stopped, as assessed by the prescriber.
Interactions
Tell your doctor if you take medicines that cause sleepiness, slow the heart’s electrical conduction, or can damage nerves outside the brain and spinal cord (peripheral neuropathy). These require caution when used with Thalomid. Medicines that stimulate red blood cell production, such as erythropoietin-stimulating agents, and estrogen-containing treatments may increase the risk of blood clots when used with Thalomid. It is not known whether hormonal contraceptives further increase this risk. Discuss any hormonal contraceptive use with your doctor.
Using Thalomid
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label THALOMID (THALIDOMIDE) CAPSULE [CELGENE CORPORATION] (DailyMed, retrieved 19 September 2026).
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