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Tepezza
Teprotumumab
$30020.00
500mg · 1 vial
BrandBranded medicine· By Amgen
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About Tepezza
Overview
Tepezza (teprotumumab) is a prescription monoclonal antibody medicine given by intravenous infusion. It treats Thyroid Eye Disease regardless of how active the disease is or how long it has been present. It binds to and blocks a receptor called IGF-1R, preventing its activation and signaling, although how this treats Thyroid Eye Disease is not fully understood.
What it treats
Thyroid eye disease, regardless of disease activity or duration.
Safety information
Side effects
Common side effects include muscle spasms, nausea, hair loss, diarrhea, tiredness, high blood sugar, hearing problems, dry skin, changes in taste, headache, weight loss and nail problems. Contact your doctor if you experience an infusion reaction, signs or symptoms of inflammatory bowel disease, high blood sugar or hearing changes. Inflammatory bowel disease can occur even in people with no previous history of it. Hearing impairment, including hearing loss, can be severe and may be permanent. Blood sugar should be checked before infusions and monitored during treatment. Hearing should be assessed before, during and after treatment.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
The label lists no contraindications to Tepezza. However, the following require caution: • Infusion reactions: If a reaction occurs, the infusion may need to be interrupted or slowed, with appropriate medical treatment. • Inflammatory bowel disease (IBD): Monitoring is needed for signs and symptoms, including in people without a history of IBD. Tepezza should be stopped if worsening IBD is suspected. • High blood sugar or diabetes: Blood sugar and symptoms of high blood sugar should be checked before infusions and monitored during treatment. Blood sugar should be appropriately controlled before and during treatment. • Hearing impairment: Tepezza may cause severe hearing impairment, including hearing loss that can be permanent. Hearing should be assessed before, during and after treatment, and the benefits and risks discussed with the patient. People who can become pregnant should use appropriate contraception before starting treatment, during treatment and for 6 months after the last dose.
Using Tepezza
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label TEPEZZA (TEPROTUMUMAB) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [HORIZON THERAPEUTICS USA, INC.] (DailyMed, retrieved 19 September 2026).
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