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Sutent
Sunitinib
$767.00
12.5mg · 28 capsules
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12.5mg
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FDA boxed warningHepatotoxicity
Hepatotoxicity may be severe, and in some cases, fatal. Monitor hepatic function and interrupt, dose reduce, or discontinue SUTENT as recommended.
About Sutent
Overview
Sutent is a prescription medicine containing sunitinib, a kinase inhibitor, in capsules. It treats adults with gastrointestinal stromal tumours (GIST) that have progressed during imatinib treatment or when imatinib cannot be tolerated, and adults with advanced renal cell carcinoma, a type of kidney cancer. It is also used in adults at high risk of kidney cancer returning after kidney removal, and for progressive, well-differentiated pancreatic neuroendocrine tumours that cannot be surgically removed and are locally advanced or have spread. It works by blocking several proteins involved in cancer cell growth, the formation of blood vessels supplying tumours, and cancer spread.
What it treats
• Gastrointestinal stromal tumour (GIST) in adults whose disease has progressed on imatinib mesylate or who cannot tolerate it. • Advanced renal cell carcinoma (RCC), a type of kidney cancer, in adults. • Treatment after kidney removal in adults at high risk of RCC returning. • Progressive, well-differentiated pancreatic neuroendocrine tumours (pNET) in adults when the disease is locally advanced and cannot be surgically removed, or has spread to other parts of the body.
Safety information
Side effects
Common side effects of Sutent (sunitinib) include tiredness or weakness, diarrhoea, inflammation or sores in the mouth, nausea, reduced appetite, vomiting, abdominal pain, hand-foot syndrome (a skin reaction affecting the palms and soles), high blood pressure, bleeding, altered taste, indigestion and a low platelet count. Contact your doctor promptly about serious side effects. These include liver damage or liver failure; heart problems, including heart attack, heart failure and abnormal heart rhythms; severe high blood pressure; serious bleeding; and a hole in an internal organ. Other serious risks include tumour lysis syndrome (complications from the rapid breakdown of tumour cells), damage to small blood vessels that can lead to kidney failure, protein in the urine, and severe skin reactions or infections, including Stevens–Johnson syndrome and toxic epidermal necrolysis. Some of these reactions have been fatal. Other serious effects include reversible posterior leukoencephalopathy syndrome (a brain condition that can be fatal), thyroid problems, low blood sugar, damage to the jawbone and impaired wound healing. Sutent can also harm an unborn baby. Regular checks of liver and thyroid function, blood pressure, blood counts, blood glucose and urine protein help monitor these risks. Heart function and heart rhythm checks may also be needed.
FDA boxed warning
Hepatotoxicity
Hepatotoxicity may be severe, and in some cases, fatal. Monitor hepatic function and interrupt, dose reduce, or discontinue SUTENT as recommended.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
The FDA label lists no contraindications for Sutent. However, it carries warnings for serious, sometimes fatal complications. Conditions requiring caution and monitoring include liver problems; heart disease, heart failure or abnormal heart rhythms; high blood pressure; bleeding; kidney problems or protein in the urine; thyroid disorders; and low blood sugar. Monitoring may include liver and thyroid tests, blood pressure, blood counts, urine protein, blood glucose, and heart tests. Other serious risks include a tear in an internal organ, complications from rapid tumour breakdown, damage to small blood vessels, severe skin reactions or tissue infections, and a brain condition called reversible posterior leukoencephalopathy syndrome. These complications may require treatment to be interrupted or stopped by the prescriber. Sutent can cause jawbone damage and impair wound healing. Tell your prescriber about planned surgery or invasive dental treatment, as treatment must be paused around these procedures. Sutent can harm an unborn baby. Effective contraception is advised. Do not breastfeed during treatment.
Interactions
Tell your doctor about all medicines and supplements you take. Strong CYP3A4 inhibitors or inducers can interact with Sutent, and your prescriber may need to adjust your treatment. Do not change your dose yourself.
Using Sutent
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label SUTENT (SUNITINIB MALATE) CAPSULE [PFIZER LABORATORIES DIV PFIZER INC] (DailyMed, retrieved 19 September 2026).
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