Soliqua, illustration of injection pen form (not a photo of the actual pack)

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Soliqua

Insulin glargine and Lixisenatide

Prescription required

$415.00

100/33 · 5 pen

BrandBranded medicine

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About Soliqua

Overview

Soliqua 100/33 is a prefilled injection pen containing insulin glargine and lixisenatide. It is used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes. It combines an ingredient that acts like insulin with one that activates GLP-1 receptors.

What it treats

- Type 2 diabetes in adults, alongside diet and exercise, to improve blood sugar control.

Safety information

Side effects

Common side effects include low blood sugar, nausea, diarrhea, headache, and nose, throat or upper respiratory infections. Serious side effects include severe allergic reactions, inflammation of the pancreas, life-threatening low blood sugar or low potassium, kidney injury due to dehydration, severe stomach or intestinal problems, and gallbladder disease. Stop using Soliqua and seek medical attention promptly if an allergic reaction occurs. Contact a doctor promptly if inflammation of the pancreas or another serious side effect is suspected. Fluid retention and heart failure can occur when Soliqua is used with medicines called PPAR-gamma agonists. Significant injection-site reactions or allergic reactions, or worsening blood sugar control, may require a change in treatment. Stomach contents entering the lungs during general anesthesia or deep sedation has been reported with GLP-1 receptor agonists. Tell your healthcare team about any planned surgery or procedure.

When to call your doctor

• An allergic reaction: stop using Soliqua and seek medical attention promptly. Severe reactions can be life-threatening. • Severe low blood sugar: seek immediate medical attention, as this can be life-threatening. • Low potassium: seek urgent medical attention, as this can be life-threatening.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not use Soliqua during an episode of low blood sugar or if you have had a serious allergic reaction to insulin glargine, lixisenatide or any other ingredient. Stop use and seek medical attention promptly if a severe allergic reaction occurs. Soliqua is not recommended for people with end-stage kidney disease or severe gastroparesis (severely delayed stomach emptying). Do not use it with another GLP-1 receptor agonist. During pregnancy, it should be used only if the potential benefit justifies the potential risk to the fetus. Close medical supervision and more frequent blood sugar checks are needed when changing an insulin regimen. Extra monitoring may also be needed with changes in other blood sugar-lowering medicines, meals or physical activity, or if you have kidney or liver problems or do not notice the warning signs of low blood sugar. Low blood sugar can be life-threatening. Other important risks include pancreatitis, severe digestive side effects, dehydration-related kidney injury, low blood potassium and gallbladder disease. Stop Soliqua if pancreatitis is suspected. Using it with PPAR-gamma agonists can cause fluid retention and heart failure. Worsening blood sugar control, significant injection-site reactions or allergic reactions may require a change in treatment. Tell your healthcare team about any planned surgery or procedure involving general anesthesia or deep sedation, because stomach contents may enter the lungs. Never share the pen, even if the needle is changed, and check the medicine label before every injection to avoid medication errors.

Interactions

Medicines that affect blood sugar may require closer blood sugar monitoring and a prescriber-directed adjustment to Soliqua treatment. Beta-blockers, clonidine, guanethidine and reserpine may make warning signs of low blood sugar less noticeable. Tell your doctor if you take any of these medicines. Soliqua slows stomach emptying, which can affect how medicines taken by mouth are absorbed. Oral contraceptives, antibiotics and acetaminophen should be taken at least 1 hour before Soliqua or 11 hours after. Ask your doctor or pharmacist to review the timing of your oral medicines.

Using Soliqua

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use and how long it may be kept at room temperature afterwards. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label SOLIQUA 100/33 (INSULIN GLARGINE AND LIXISENATIDE) INJECTION, SOLUTION [SANOFI-AVENTIS U.S. LLC] (DailyMed, retrieved 19 September 2026).

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