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Seroquel
Quetiapine Fumarate
$144.00
25mg · 6 × 30 tablets · 3 months supply
BrandBranded medicine· By Astra Zeneca
$48.00 per month
Strength
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Annual cost
$576a year at this pack size
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FDA boxed warningIncreased mortality in elderly patients with dementia-related psychosis; and suicidal thoughts and behaviors
Increased Mortality in Elderly Patients with Dementia-Related Psychosis
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. SEROQUEL is not approved for the treatment of patients with dementia-related psychosis.
Suicidal Thoughts and Behaviors
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older.
SEROQUEL is not approved for use in pediatric patients under ten years of age.
- Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. SEROQUEL is not approved for elderly patients with dementia-related psychosis
About Seroquel
Overview
Seroquel is an atypical antipsychotic tablet containing quetiapine as quetiapine fumarate. It is used to treat schizophrenia, manic episodes in bipolar I disorder, and depressive episodes in bipolar disorder. Its exact mechanism is unclear, but it may work by blocking certain receptors for dopamine and serotonin, two chemical messengers in the brain.
What it treats
- Schizophrenia - Manic episodes associated with bipolar I disorder - Depressive episodes associated with bipolar disorder
Safety information
Side effects
Common side effects in adults include sleepiness, dry mouth, dizziness, constipation, weakness, stomach pain, low blood pressure on standing, sore throat, weight gain, sluggishness, indigestion and increased levels of the liver enzyme ALT. In children and adolescents, common side effects include sleepiness, dizziness, tiredness, increased appetite, nausea, vomiting, dry mouth, a fast heartbeat and weight gain. Serious risks include suicidal thoughts or behaviours in adolescents and young adults, stroke and increased risk of death in older people with dementia-related psychosis, neuroleptic malignant syndrome, seizures, abnormal heart rhythms associated with QT prolongation, and involuntary movements known as tardive dyskinesia. Seek immediate medical attention for suicidal thoughts or behaviours, a seizure, or suspected stroke or neuroleptic malignant syndrome. Contact a doctor about involuntary movements, difficulty swallowing, falls, vision changes, or increased thirst, urination or hunger with weakness, which may indicate high blood sugar. Other serious effects include diabetes, abnormal blood fat levels, weight gain, low white blood cell counts, low thyroid function, raised prolactin levels, cataracts, problems regulating body temperature, and impaired thinking or movement. Blood pressure may fall, or may rise in children and adolescents. Urinary retention and constipation are also concerns, particularly with other medicines that have anticholinergic effects. Symptoms may occur after stopping treatment. Monitoring may include blood sugar, blood fats, weight, blood pressure, blood counts and eye examinations.
FDA boxed warning
Increased mortality in elderly patients with dementia-related psychosis; and suicidal thoughts and behaviors
Increased Mortality in Elderly Patients with Dementia-Related Psychosis
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. SEROQUEL is not approved for the treatment of patients with dementia-related psychosis.
Suicidal Thoughts and Behaviors
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older.
SEROQUEL is not approved for use in pediatric patients under ten years of age.
- Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. SEROQUEL is not approved for elderly patients with dementia-related psychosis
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Seroquel if you are allergic to quetiapine or any of its ingredients. Severe allergic reactions, including anaphylaxis, have been reported. Conditions requiring caution or monitoring include: • Heart or blood vessel disease, or disease affecting blood vessels in the brain, because of the risk of low blood pressure. • Dementia-related psychosis in older adults: atypical antipsychotics have been linked to an increased risk of stroke and transient ischaemic attack (TIA). • Diabetes or risk factors for diabetes. Blood glucose should be monitored regularly in these patients. Increased thirst, frequent urination, increased hunger or weakness may indicate high blood sugar. • Abnormal blood fats or weight gain. Blood lipid testing and weight monitoring are recommended. • A low white blood cell count or a history of low white blood cells. Frequent blood counts are recommended during the first few months of treatment. • Urinary retention, an enlarged prostate or constipation, or use of other medicines with anticholinergic effects. • Pregnancy: exposure during the third trimester may cause movement problems or withdrawal symptoms in newborns. Blood pressure monitoring is recommended for children and adolescents. Eye lens examinations are recommended when treatment starts and every six months during long-term treatment because lens changes have been reported. Neuroleptic malignant syndrome requires immediate discontinuation and close monitoring. If tardive dyskinesia develops, the prescriber may consider stopping treatment.
Interactions
Tell your doctor if you take ketoconazole, ritonavir, phenytoin, rifampin or the herbal supplement St. John’s wort. These can affect quetiapine levels, and your prescriber may need to adjust your dose. Speak with your doctor before starting or stopping any of these medicines or supplements.
Using Seroquel
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label SEROQUEL (QUETIAPINE) TABLET, FILM COATED [H2-PHARMA, LLC] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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