Poteligeo, illustration of injection vial form (not a photo of the actual pack)

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Poteligeo

Mogamulizumab‑kpkc

Prescription required

$2630.00

4mg/ml · 1 vial

BrandBranded medicine· By Kyowa Kirin

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About Poteligeo

Overview

Poteligeo (mogamulizumab-kpkc) is a monoclonal antibody medicine given by intravenous infusion. It treats adults with mycosis fungoides or Sézary syndrome that has returned or has not responded to treatment, after at least one prior treatment that acts throughout the body. It binds to a protein called CCR4 on certain cells, including some cancerous T cells, helping the immune system destroy those cells.

What it treats

- Mycosis fungoides or Sézary syndrome in adults whose disease has returned or has not responded to treatment after at least one prior systemic therapy (treatment that works throughout the body).

Safety information

Side effects

Common side effects of Poteligeo include rash, reactions during an infusion, tiredness, diarrhoea, muscle and joint pain, and upper respiratory tract infections. Each was reported in at least 20% of patients. Contact your doctor promptly if you develop a rash, an infusion reaction, an infection or an autoimmune complication, in which the immune system attacks the body’s own tissues. Skin rashes and infusion reactions can be life-threatening and may require treatment to be interrupted or permanently stopped. Serious complications can occur after an allogeneic haematopoietic stem cell transplant (a transplant using donor stem cells) following Poteligeo treatment. These include severe acute graft-versus-host disease, including cases that do not respond to steroid treatment. Transplant-related deaths have occurred.

When to call your doctor

- Seek medical attention immediately for a new or worsening skin rash. - Tell your care team immediately about any reaction during an infusion. - Contact your doctor promptly if you develop signs of an infection.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

The FDA label lists no contraindications for Poteligeo. Important cautions include skin rashes, infusion reactions, infections and autoimmune complications. Treatment must be paused for moderate or severe skin rashes or any infusion reaction, and permanently stopped if the rash or infusion reaction is life-threatening. Infections need monitoring and prompt treatment. Autoimmune complications may require treatment to be paused or permanently stopped. People who undergo an allogeneic haematopoietic stem cell transplant (a transplant using donor cells) after Poteligeo need monitoring for severe acute graft-versus-host disease and graft-versus-host disease that does not respond to steroids. Transplant-related deaths have occurred.

Using Poteligeo

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label POTELIGEO (MOGAMULIZUMAB-KPKC) INJECTION [KYOWA KIRIN, INC.] (DailyMed, retrieved 19 September 2026).

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