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Pluvicto
Lutetium Lu 177 vipivotide Tetraxetan
$42980.00
12.5ML · 1 vial
BrandBranded medicine· By Novartis
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About Pluvicto
Overview
Pluvicto (lutetium Lu 177 vipivotide tetraxetan) is a prescription radioactive medicine supplied in a vial for injection into a vein. It is used with an androgen receptor pathway inhibitor (ARPI) to treat adults with PSMA-positive prostate cancer that has spread and has not yet been treated with, or remains sensitive to, androgen pathway modulation. It is also used for adults whose PSMA-positive prostate cancer has spread and is resistant to androgen pathway modulation, after ARPI treatment, when delaying taxane-based chemotherapy is considered appropriate or taxane-based chemotherapy has already been given. It binds to a protein called PSMA and delivers radiation to cells carrying that protein and nearby cells, damaging their DNA and potentially causing cell death.
What it treats
- PSMA-positive metastatic androgen pathway modulation-naïve or -sensitive prostate cancer in adults, in combination with androgen receptor pathway inhibitor (ARPI) therapy. - PSMA-positive metastatic androgen pathway modulation-resistant prostate cancer in adults previously treated with ARPI therapy who are considered suitable to delay taxane-based chemotherapy or have already received it.
Safety information
Side effects
Common side effects include tiredness, dry mouth and nausea. Common blood test changes include low levels of lymphocytes and neutrophils (types of white blood cells), hemoglobin and platelets; reduced kidney filtration; increased liver enzymes; low sodium and calcium; and high magnesium and potassium. Serious risks that warrant contacting your doctor include bone marrow suppression, which reduces blood cell counts, and kidney damage. Blood counts and kidney function need to be monitored. Depending on the severity, treatment may need to be paused, adjusted or stopped permanently. Pluvicto involves radiation exposure. Follow your treatment team’s radiation safety instructions, drink more fluids and urinate frequently to reduce radiation exposure to the bladder. It can harm an unborn baby; men with female partners who could become pregnant should use effective contraception. Pluvicto may also cause temporary or permanent infertility.
Before taking this medicine
The FDA label lists no contraindications for Pluvicto. Pluvicto requires precautions to limit radiation exposure during and after treatment. Patients should increase fluid intake and urinate frequently to reduce radiation exposure to the bladder. Pluvicto can suppress blood cell production and cause kidney toxicity. Complete blood counts and kidney function tests are required. Depending on severity, the prescriber may pause, adjust or permanently stop treatment. Pluvicto can harm an unborn baby. Men with female partners who could become pregnant should use effective contraception. It may also cause temporary or permanent infertility.
Using Pluvicto
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label PLUVICTO (LUTETIUM LU 177 VIPIVOTIDE TETRAXETAN) INJECTION, SOLUTION [NOVARTIS PHARMACEUTICALS CORPORATION] (DailyMed, retrieved 19 September 2026).
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