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Paxlovid
Nirmatrelvir + Ritonavir
$1540.00
150/100mg · 30 tablets
BrandBranded medicine· By Pfizer
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FDA boxed warningSignificant drug interactions with paxlovid
PAXLOVID includes ritonavir, a strong CYP3A inhibitor, which may lead to greater exposure of certain concomitant medications, resulting in potentially severe, life-threatening, or fatal events.
Prior to prescribing PAXLOVID: 1) Review all medications taken by the patient to assess potential drug-drug interactions with a strong CYP3A inhibitor like PAXLOVID and 2) Determine if concomitant medications require a dose adjustment, interruption, and/or additional monitoring.
Consider the benefit of PAXLOVID treatment in reducing hospitalization and death, and whether the risk of potential drug-drug interactions for an individual patient can be appropriately managed.
About Paxlovid
Overview
Paxlovid is a prescription medicine containing nirmatrelvir and ritonavir tablets packaged together. It treats mild-to-moderate COVID-19 in adults at high risk of developing severe illness, including hospitalization or death. Nirmatrelvir blocks a key enzyme in the virus that causes COVID-19, while ritonavir slows the breakdown of nirmatrelvir to increase its levels in the blood. Paxlovid is not approved to prevent COVID-19 before or after exposure.
What it treats
Treatment of mild-to-moderate COVID-19 in adults at high risk of progression to severe illness, including hospitalization or death.
Safety information
Side effects
The most common side effects are an altered sense of taste and diarrhea. Serious reactions reported with Paxlovid include severe allergic reactions, including anaphylaxis, and severe skin reactions, including Stevens–Johnson syndrome and toxic epidermal necrolysis. Stop taking Paxlovid and seek immediate medical attention if signs of a serious allergic or skin reaction occur. Raised liver enzymes, liver inflammation (hepatitis) and jaundice have occurred in people receiving ritonavir, one of Paxlovid’s active ingredients. Contact a doctor if you develop jaundice (yellowing of the skin or eyes). Paxlovid can also cause potentially significant interactions with certain other medicines. In people with uncontrolled or undiagnosed HIV-1 infection, it may increase the risk of HIV-1 developing resistance to HIV protease inhibitors.
FDA boxed warning
Significant drug interactions with paxlovid
PAXLOVID includes ritonavir, a strong CYP3A inhibitor, which may lead to greater exposure of certain concomitant medications, resulting in potentially severe, life-threatening, or fatal events.
Prior to prescribing PAXLOVID: 1) Review all medications taken by the patient to assess potential drug-drug interactions with a strong CYP3A inhibitor like PAXLOVID and 2) Determine if concomitant medications require a dose adjustment, interruption, and/or additional monitoring.
Consider the benefit of PAXLOVID treatment in reducing hospitalization and death, and whether the risk of potential drug-drug interactions for an individual patient can be appropriately managed.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Paxlovid if you have had a clinically significant allergic reaction to nirmatrelvir, ritonavir or any other ingredient, including severe skin reactions such as Stevens–Johnson syndrome or toxic epidermal necrolysis. Paxlovid must not be taken together with the following medicines because interactions can cause serious or life-threatening reactions: alfuzosin; ranolazine; amiodarone, dronedarone, flecainide, propafenone or quinidine; lurasidone or pimozide; silodosin; eplerenone or ivabradine; dihydroergotamine, ergotamine or methylergonovine; lovastatin or simvastatin; voclosporin; lomitapide; eletriptan or ubrogepant; finerenone; suzetrigine; naloxegol; triazolam or oral midazolam; flibanserin; or tolvaptan. It must also not be taken with sildenafil when used for pulmonary arterial hypertension, or with colchicine if you have kidney or liver impairment. A prescriber may temporarily stop lovastatin or simvastatin to allow Paxlovid treatment. Do not take Paxlovid with apalutamide, enzalutamide, carbamazepine, phenobarbital, primidone, phenytoin, rifampin, rifapentine, lumacaftor/ivacaftor or St. John’s wort. These medicines can lower Paxlovid levels, potentially reducing its antiviral effect and allowing resistance to develop. Paxlovid cannot be started immediately after stopping them because their effects on drug breakdown persist. This is not a complete list of interacting medicines. Your healthcare provider should review potential interactions before and during treatment. Some other medicines may need to be avoided, temporarily stopped, adjusted or monitored. Serious allergic reactions, including anaphylaxis and severe skin reactions, have been reported. Stop Paxlovid immediately and seek urgent medical care if signs of a serious allergic reaction occur. Ritonavir has also been associated with raised liver enzymes, hepatitis and jaundice. In people with uncontrolled or undiagnosed HIV-1 infection, Paxlovid may increase the risk of HIV-1 becoming resistant to HIV protease inhibitors.
Interactions
Paxlovid can change the levels of other medicines in your blood, and other medicines can change the levels of Paxlovid. Review all medicines you take with your doctor before starting Paxlovid and during treatment so they can check for potential interactions.
Using Paxlovid
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label PAXLOVID (NIRMATRELVIR AND RITONAVIR) KIT [PFIZER LABORATORIES DIV PFIZER INC] (DailyMed, retrieved 19 September 2026).
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