Novolog, illustration of injection pen form (not a photo of the actual pack)

Illustrative image.

Novolog

Insulin aspart

Prescription required

$67.00

empty · 5 pen

BrandBranded medicine· By Novo Nordisk

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100 iu/ml

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About Novolog

Overview

Novolog contains insulin aspart, a rapid-acting human insulin analog. It is used to improve blood sugar control in adults and children with diabetes mellitus. It lowers blood sugar by helping muscle and fat cells take up glucose and reducing the amount of glucose produced by the liver.

What it treats

Diabetes mellitus in adults and children, to improve blood sugar control.

Safety information

When to call your doctor

- Very low blood sugar, which can be life-threatening. - A severe allergic reaction. - Fluid retention or signs of heart failure while also taking a thiazolidinedione (TZD) medicine. - High blood sugar or ketoacidosis following an insulin pump malfunction.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not use NovoLog during an episode of low blood sugar (hypoglycemia) or if you are allergic to insulin aspart or any of its other ingredients. Extra caution and more frequent blood sugar checks may be needed if you have kidney or liver problems, do not notice the warning signs of low blood sugar, or have changes in meals, physical activity or other blood sugar-lowering medicines. Low blood sugar can be life-threatening. Changes to your insulin treatment, injection site or method of administration should be made under close medical supervision. NovoLog can cause severe allergic reactions, including anaphylaxis, and dangerously low potassium levels. People at risk of low potassium may need blood tests. Taking NovoLog with thiazolidinediones (TZDs) can cause fluid retention and heart failure and requires monitoring. Never share pens, cartridges or cartridge devices, even if the needle is changed. Check the insulin label before every injection to avoid mix-ups. If you use an insulin pump, a malfunction can cause high blood sugar and ketoacidosis; monitor your blood sugar and use NovoLog by injection under the skin if the pump fails.

Interactions

Other diabetes medicines, ACE inhibitors, angiotensin II receptor blockers, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogues such as octreotide, and sulfonamide antibiotics may increase the risk of low blood sugar with Novolog. Medicines that may reduce Novolog’s blood sugar-lowering effect include atypical antipsychotics such as olanzapine and clozapine, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens, protease inhibitors, somatropin, sympathomimetic medicines such as albuterol, epinephrine and terbutaline, and thyroid hormones. Alcohol, beta-blockers, clonidine and lithium salts may either increase or decrease Novolog’s blood sugar-lowering effect. Pentamidine may cause low blood sugar, sometimes followed by high blood sugar. Beta-blockers, clonidine, guanethidine and reserpine may make the warning signs of low blood sugar less noticeable. Discuss these combinations with your doctor. More frequent blood sugar checks may be needed, and your prescriber may need to adjust your insulin dose.

Using Novolog

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use and how long it may be kept at room temperature afterwards. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label NOVOLOG (INSULIN ASPART) INJECTION, SOLUTION INSULIN DILUTING MEDIUM FOR NOVOLOG (WATER INJECTION) INJECTION, SOLUTION [NOVO NORDISK] (DailyMed, retrieved 19 September 2026).

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