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Norpramin
Desipramine Hydrochloride
$100.00
25 mg · 100 tablets · 3 months supply
BrandBranded medicine
$33.33 per month
How long a supply?
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Annual cost
$400a year at this pack size
Prescription required
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FDA boxed warning
Suicidality and Antidepressant Drugs
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of desipramine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Desipramine hydrochloride is not approved for use in pediatric patients (see WARNINGS: Clinical Worsening and Suicide Risk, PRECAUTIONS: Information for Patients, and PRECAUTIONS: Pediatric Use.)
About Norpramin
Overview
Norpramin contains desipramine hydrochloride, a tricyclic antidepressant. It is a prescription medicine used to treat depression. Its exact action is not fully understood, but it is thought to work by reducing the reuptake of chemical messengers in the brain, particularly norepinephrine, making them more available between nerve cells.
What it treats
Depression.
Safety information
Side effects
Possible side effects include dry mouth, constipation, nausea, vomiting, stomach discomfort, diarrhea, blurred vision, dizziness, drowsiness, headache, sweating, weakness and fatigue. Changes in appetite, weight, sleep or sexual function may also occur. The label does not state how often these effects occur. Drowsiness and dizziness may affect driving or operating machinery, and unsteadiness may increase the risk of falls. Contact a doctor immediately for worsening depression, suicidal thoughts, agitation, unusual behavior changes, hallucinations or unusually elevated mood. Antidepressants increase the risk of suicidal thoughts and behavior in children, adolescents and young adults aged 18 to 24. Close monitoring is especially important early in treatment and when the prescribed dose changes. Seek urgent medical attention for: • Fast or irregular heartbeat, collapse or seizures. Serious heart rhythm disturbances, heart attack, stroke and sudden death have been reported, including reports of sudden death in children. • Possible serotonin syndrome: agitation or confusion together with fever, sweating, tremor, muscle stiffness, poor coordination, vomiting or diarrhea. This can be life-threatening. • Possible low blood sodium: headache, difficulty concentrating, confusion, weakness or unsteadiness. Severe cases can cause fainting, seizures or coma. • Swelling of the face or tongue, hives or other allergic reactions. • Difficulty passing urine, severe constipation or new vision problems. Urinary retention, bowel paralysis, increased eye pressure and angle-closure glaucoma can occur. • Yellowing of the skin or eyes, unusual bruising or bleeding, or fever. Liver injury and serious blood-cell disorders are listed reactions. Stopping suddenly after prolonged treatment may cause nausea, headache and feeling unwell; these withdrawal symptoms do not indicate addiction. Some reactions in the label were reported with related tricyclic antidepressants rather than specifically with desipramine, but should still be considered during treatment.
FDA boxed warning
Suicidality and Antidepressant Drugs
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of desipramine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Desipramine hydrochloride is not approved for use in pediatric patients (see WARNINGS: Clinical Worsening and Suicide Risk, PRECAUTIONS: Information for Patients, and PRECAUTIONS: Pediatric Use.)
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take desipramine if you: • Have previously had an allergic reaction to desipramine. Cross-sensitivity with other dibenzazepine medicines is possible. • Are in the immediate recovery period after a heart attack. • Take a monoamine oxidase inhibitor (MAOI) for a psychiatric condition, or stopped one within the past 14 days. An MAOI for a psychiatric condition must also not be started within 14 days of stopping desipramine. • Are currently receiving linezolid or intravenous methylene blue. Tell your prescriber before treatment if you have heart or blood vessel disease; a family history of sudden death, abnormal heart rhythms or heart conduction problems; difficulty emptying your bladder; glaucoma or anatomically narrow drainage angles in the eye; thyroid disease or take thyroid medication; or a history of seizures. These conditions require particular caution. Patients should be screened for bipolar disorder before starting treatment. Desipramine is not approved for bipolar depression. Antidepressants increase the risk of suicidal thoughts and behaviour in children, adolescents and young adults aged 18–24. All patients need close monitoring for worsening depression, suicidal thoughts or unusual behaviour changes, especially early in treatment or when the prescribed dose changes. Report these changes immediately to a healthcare professional. Other medicines that affect serotonin, including some antidepressants, triptans, fentanyl, lithium, tramadol, buspirone, tryptophan and St. John’s wort, can increase the risk of potentially life-threatening serotonin syndrome. Desipramine can also reduce the blood-pressure-lowering effect of guanethidine and similar medicines. Low blood sodium can occur, with greater risk in older people, people taking diuretics and those with depleted fluid levels. Older people may also be at greater risk of toxic effects because of reduced kidney clearance. Safety during pregnancy and breastfeeding has not been established; the prescriber should weigh the possible benefits against risks to mother and child. Desipramine may impair driving or machinery use. Excessive alcohol use can increase the dangers of overdose.
Using Norpramin
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label DESIPRAMINE HYDROCHLORIDE TABLET, FILM COATED [ACTAVIS PHARMA, INC.] (DailyMed, retrieved 19 September 2026).
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