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Naprosyn
Naproxen Sodium
$72.00
250mg · 4 × 50 tablets · 3 months supply
GenericGeneric medicine· By Teva
$24.00 per month
Strength
How long a supply?
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Annual cost
$270a year at this pack size
Prescription required
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250mg
500mg
FDA boxed warningRisk of serious cardiovascular and gastrointestinal events
Cardiovascular Thrombotic Events
- Naproxen Tablets are contraindicated in the setting of coronary artery bypass graft (CABG) surgery
Gastrointestinal Bleeding, Ulceration, and Perforation
- NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events
About Naprosyn
Overview
Naprosyn is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation. It treats symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendonitis, bursitis and acute gout, and is also used for pain and menstrual cramps. It works in part by reducing the production of prostaglandins, substances involved in pain and inflammation.
What it treats
- Rheumatoid arthritis - Osteoarthritis - Ankylosing spondylitis - Polyarticular juvenile idiopathic arthritis - Tendonitis - Bursitis - Acute gout - Pain - Primary dysmenorrhea (menstrual pain)
Safety information
Side effects
Common side effects include indigestion, stomach pain, nausea, headache, skin rash, bruising and swelling from fluid retention. Serious side effects include blood clots affecting the heart or blood vessels; bleeding, ulcers or holes in the stomach or intestines; liver damage; high blood pressure; worsening heart failure; kidney damage; high potassium levels; and blood problems, including anemia. Contact a doctor promptly if you suspect a serious side effect. Stop taking naproxen and contact a doctor at the first sign of a skin rash or other signs of an allergic reaction. Serious skin reactions and DRESS, a potentially serious drug reaction that can affect several parts of the body, can occur. Seek emergency help for a severe allergic reaction (anaphylaxis). Naproxen can also worsen asthma in people who are sensitive to aspirin and must not be used by people with aspirin-sensitive asthma.
FDA boxed warning
Risk of serious cardiovascular and gastrointestinal events
Cardiovascular Thrombotic Events
- Naproxen Tablets are contraindicated in the setting of coronary artery bypass graft (CABG) surgery
Gastrointestinal Bleeding, Ulceration, and Perforation
- NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take naproxen if you are allergic to naproxen or any tablet ingredient, or if aspirin or another nonsteroidal anti-inflammatory drug (NSAID) has caused asthma, hives or another allergic reaction. Do not use it in connection with coronary artery bypass graft (CABG) surgery. Naproxen is not recommended for people with severe kidney impairment. It should be avoided in advanced kidney disease or severe heart failure unless the prescriber considers that the benefits outweigh the risks. Tell your prescriber if you have kidney or liver problems, heart failure, dehydration, low blood volume, high blood pressure or asthma. Kidney function and blood pressure may need monitoring. Naproxen can reduce the effect of some blood pressure medicines. Signs or symptoms of anemia may require blood tests. Use during pregnancy should be limited between about 20 and 30 weeks because of risks to the unborn baby’s kidneys and low amniotic fluid. Avoid use from about 30 weeks onward because it can also cause early closure of a blood vessel in the unborn baby’s heart. If you are having difficulty conceiving, discuss stopping naproxen with your prescriber; NSAIDs can cause reversible fertility problems. Stop taking naproxen at the first sign of a skin rash or another allergic reaction. Seek emergency help for a severe allergic reaction. A serious drug reaction called DRESS also requires stopping treatment and medical assessment. Treatment should be stopped if abnormal liver tests persist or worsen, or signs of liver disease develop.
Interactions
Naproxen can interact with the following medicines: Blood thinners such as warfarin, antiplatelet medicines such as aspirin, and SSRI or SNRI antidepressants can increase bleeding risk when taken with naproxen. Your doctor may need to monitor for bleeding. Aspirin: Naproxen can interfere with aspirin’s protective effect against blood clots and is not a substitute for aspirin used for heart protection. Taking aspirin for pain relief alongside naproxen is generally not recommended because of increased bleeding and stomach or bowel risks. Other NSAIDs and salicylates, including diflunisal and salsalate: Combining these with naproxen is not recommended because it increases stomach and bowel risks with little or no added benefit. Blood pressure medicines and diuretics: Naproxen may reduce the effects of ACE inhibitors, angiotensin receptor blockers (ARBs), beta-blockers and certain diuretics. Kidney problems may also occur, particularly with ACE inhibitors or ARBs in older people, those who are dehydrated or those with existing kidney problems. Blood pressure and kidney function may need monitoring. Digoxin and lithium: Naproxen can increase their levels in the blood. Your doctor may monitor digoxin levels or check for lithium toxicity. Methotrexate, cyclosporine and pemetrexed: Naproxen may increase their harmful effects, including kidney damage. Methotrexate and pemetrexed may also cause increased blood-cell problems, and pemetrexed may cause increased stomach or bowel problems. Monitoring may be needed. Certain antacids containing magnesium oxide or aluminum hydroxide, sucralfate and cholestyramine can delay naproxen absorption. Taking these together with naproxen is not recommended. Probenecid can increase naproxen levels and make it remain in the body longer. Hydantoins, sulphonamides and sulphonylureas also require review and monitoring when taken with naproxen. Tell your doctor if you are having laboratory tests. Naproxen can prolong bleeding time and interfere with certain adrenal function tests and urine tests for 5-HIAA.
Using Naprosyn
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label NAPROXEN TABLET [REMEDYREPACK INC.] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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