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Lutathera
Lutetium Lu 177 Dotatate
$40290.00
1 vial
BrandBranded medicine· By Novartis
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About Lutathera
Overview
Lutathera (lutetium Lu 177 dotatate) is a radioactive medicine supplied in a vial for intravenous use. It treats gastroenteropancreatic neuroendocrine tumors (GEP-NETs) that have somatostatin receptors in adults and children aged 12 years and older. It attaches to these receptors and delivers radiation that damages the receptor-bearing cells and nearby cells.
What it treats
- Somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut and hindgut tumors, in adults and children aged 12 years and older.
Safety information
Side effects
The label lists the most common severe side effects as low levels of lymphocytes (a type of white blood cell), increased liver enzymes, vomiting, nausea, high blood sugar and low potassium. Serious risks that warrant contacting your doctor include reduced blood cell production, kidney or liver damage, severe allergic reactions including anaphylaxis, and a hormone-related crisis. Signs of a hormone-related crisis can include flushing, diarrhea, low blood pressure or narrowed airways. Seek immediate medical help for signs of a severe allergic reaction or breathing difficulty. Lutathera can also cause myelodysplastic syndrome (a bone marrow disorder) and leukemia, which may develop months or years after treatment. Blood counts, kidney function and liver function need monitoring. Lutathera can harm an unborn baby and may cause infertility. Females and males who could conceive a child should use effective contraception. Follow your care team’s instructions to limit radiation exposure during and after treatment.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
The FDA label lists no contraindications for Lutathera. However, it carries important risks and requires close monitoring. Lutathera can cause low blood cell counts, kidney or liver toxicity, serious allergic reactions including anaphylaxis, and later development of myelodysplastic syndrome or acute leukemia. Blood counts, kidney function and liver tests should be monitored. Treatment may need to be changed or stopped depending on the severity of adverse effects. Radiation exposure must be minimized during and after treatment. Patients should stay hydrated and urinate frequently before treatment, on the treatment day and the following day. Monitoring is also needed for a neuroendocrine hormonal crisis, which may cause flushing, diarrhea, low blood pressure or narrowing of the airways. Lutathera can harm an unborn baby. Females and males of reproductive potential should use effective contraception. Do not breastfeed during treatment. Lutathera may also cause infertility.
Interactions
Tell your doctor if you use somatostatin analogs, including long-acting treatments or short-acting octreotide. These medicines need to be paused before each Lutathera treatment. Your doctor will tell you when to stop them.
Using Lutathera
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label LUTATHERA (LUTETIUM LU 177 DOTATATE) INJECTION [ADVANCED ACCELERATOR APPLICATIONS USA, INC] (DailyMed, retrieved 19 September 2026).
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