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Keytruda
Pembrolizumab
$4115.00
100mg/4mL · 1 vial
BrandBranded medicine· By Merck
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About Keytruda
Overview
Keytruda (pembrolizumab) is a prescription cancer medicine supplied in a vial for intravenous use. It is used alone or with other treatments for certain cancers, including melanoma, non-small cell lung cancer, and some breast, bladder and kidney cancers, depending on the cancer’s stage, test results and previous treatment. It works by blocking PD-1, a protein on immune cells that can limit their response to cancer, helping restore the immune response against tumors.
What it treats
Keytruda is used alone or with other treatments for selected cases of: • Melanoma. • Non-small cell lung cancer. • Malignant pleural mesothelioma. • Head and neck squamous cell cancer. • Classical Hodgkin lymphoma. • Primary mediastinal large B-cell lymphoma. • Urothelial cancer, including certain bladder cancers. • Colorectal cancer with MSI-H or dMMR biomarkers. • Gastric, gastroesophageal junction and esophageal cancers. • Cervical cancer. • Hepatocellular carcinoma related to hepatitis B. • Biliary tract cancer. • Merkel cell carcinoma. • Renal cell carcinoma. • Endometrial carcinoma. • Cutaneous squamous cell carcinoma. • Triple-negative breast cancer. • Platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer. • Solid tumors with MSI-H, dMMR or high tumor mutational burden biomarkers. Eligibility depends on the specific cancer, its stage, previous treatment and, for some uses, tumor test results. Certain uses involve treatment before or after surgery.
Safety information
Side effects
Common side effects of Keytruda used alone include tiredness, muscle or bone pain, rash, diarrhoea, fever, cough, reduced appetite, itching, shortness of breath, constipation, pain, abdominal pain, nausea and an underactive thyroid. When Keytruda is used with other cancer treatments, common side effects vary by combination. They may also include vomiting, weakness, hair loss, nerve problems, mouth sores, headache, weight loss, joint or muscle pain, trouble sleeping, redness and soreness of the palms and soles, urinary tract infections, high blood pressure, changes in voice, dry eyes and changes in taste. Some combinations commonly cause low blood cell counts, raised liver enzymes, liver damage, bleeding, protein in the urine or acute kidney injury. Contact a doctor promptly about serious side effects. Keytruda can cause the immune system to attack any organ or tissue. These reactions can be severe or fatal and include inflammation of the lungs, bowel, liver or kidneys, hormone-gland disorders, serious skin reactions and rejection of a transplanted organ. Liver, kidney and thyroid blood tests are needed before and periodically during treatment to help identify problems. Reactions during an infusion may require the infusion to be slowed, interrupted or permanently stopped. Report any reaction during an infusion immediately. Serious or fatal complications can also occur in people who receive a donor stem cell transplant before or after Keytruda treatment. Keytruda can harm an unborn baby.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
The FDA label lists no formal contraindications for Keytruda (pembrolizumab). However, important warnings and precautions apply. Keytruda can cause immune-related reactions affecting any organ or tissue. These may be severe or fatal and can include inflammation of the lungs, bowel, liver, kidneys or skin, hormone gland disorders, and rejection of a transplanted organ. Liver enzymes, kidney function and thyroid function should be checked before and periodically during treatment. Treatment may need to be withheld or permanently stopped depending on the reaction. Infusion-related reactions may require the infusion to be slowed, interrupted or permanently stopped. Serious or fatal complications can occur in people who receive an allogeneic stem cell transplant (using donor cells) before or after treatment. For multiple myeloma, combining Keytruda with a thalidomide analogue and dexamethasone is not recommended outside controlled clinical trials. Keytruda can harm an unborn baby. People who can become pregnant should use effective contraception. Do not breastfeed during treatment.
Using Keytruda
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton below 25°C, protected from light, unless the pack states refrigeration. Do not freeze. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label KEYTRUDA (PEMBROLIZUMAB) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION KEYTRUDA (PEMBROLIZUMAB) INJECTION, SOLUTION [MERCK SHARP & DOHME LLC ] (DailyMed, retrieved 19 September 2026).
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