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Gilotrif

Name: Gilotrif
Brand: Boehringer Ingelheim
Availability: InStock

Afatinib (dimaleate)

Prescription required

$10755.00

30mg · 3 × 28 tablets · 3 months supply

BrandBranded medicine· By Boehringer Ingelheim

$3585.00 per month

Strength

How long a supply?

1 month$3585.00 a monthOne-off$3585.00

3 months$3585.00 a monthOne-off$10755.00

6 months$3585.00 a monthOne-off$21510.00

Supplied from Israel

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Annual cost

$46605a year at this pack size

Prescription required

Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.

20mg

30mg

40mg

About Gilotrif

Overview

Gilotrif contains afatinib (as afatinib dimaleate), a kinase inhibitor. It is used as a first treatment for non-small cell lung cancer that has spread to other parts of the body and has non-resistant EGFR mutations detected by an FDA-approved test. It is also used for squamous non-small cell lung cancer that has spread and progressed after platinum-based chemotherapy. It works by blocking signals from EGFR and related proteins that can support cancer cell growth.

What it treats

- First-line treatment of metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations confirmed by an FDA-approved test. Safety and effectiveness have not been established for tumors with resistant EGFR mutations. - Metastatic squamous NSCLC that has progressed after platinum-based chemotherapy.

Safety information

Side effects

Common side effects include diarrhea, rash or acne-like skin inflammation, mouth sores or inflammation, inflammation around the nails, dry skin, reduced appetite, nausea, vomiting and itching. Contact a doctor promptly for severe or prolonged diarrhea, especially if it does not respond to anti-diarrheal treatment, as it can cause dehydration and kidney failure. Severe or persistent skin reactions, including blistering or peeling, also need prompt medical attention and can be life-threatening. Other serious side effects include inflammation of the lung tissue, liver damage that can be fatal, a hole in the stomach or intestine, and inflammation or ulceration of the cornea of the eye. Contact a doctor promptly for new or worsening breathing symptoms or suspected serious side effects. Regular liver tests are needed during treatment. Gilotrif can harm an unborn baby. Contact your doctor if you are pregnant or become pregnant during treatment. Use effective contraception if you can become pregnant.

When to call your doctor

- Seek immediate medical attention for severe or prolonged diarrhea that does not improve with anti-diarrhea medicine. - Seek immediate medical attention for severe blistering, peeling skin, or a severe or persistent skin reaction. - Seek immediate medical attention for new or worsening breathing problems. - Seek immediate medical attention for inflammation or ulceration of the eye’s surface.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

The FDA label lists no contraindications for Gilotrif. However, it includes important warnings: • Diarrhea can lead to dehydration and kidney failure. Severe, prolonged diarrhea that does not respond to anti-diarrheal medicines requires treatment to be withheld. • Severe blistering or peeling skin reactions require treatment to be withheld. Life-threatening skin reactions require treatment to be stopped. • New or worsening breathing symptoms require treatment to be withheld while being assessed. Gilotrif must be stopped if interstitial lung disease is diagnosed. • Liver injury, including fatal liver impairment, can occur. Periodic liver tests are needed; severe or worsening results may require treatment to be withheld or stopped. • A hole in the stomach or intestine can occur and requires permanent discontinuation. • Inflammation of the cornea (keratitis) requires treatment to be withheld for assessment. Confirmed ulcerative keratitis may require treatment to be withheld or stopped. Gilotrif can harm an unborn baby. Women who are pregnant should be advised of this risk, and women who could become pregnant should use effective contraception. Do not breastfeed during treatment.

Interactions

Medicines that block P-glycoprotein (P-gp) can increase the amount of afatinib in your body. Long-term use of oral medicines that increase P-gp activity can lower the amount of afatinib in your body. Tell your doctor about medicines you take, as these interactions may require your prescriber to adjust your Gilotrif treatment.

Using Gilotrif

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label GILOTRIF (AFATINIB) TABLET, FILM COATED [BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).

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