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Erythromycin
Erythromycin
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About Erythromycin
Overview
Erythromycin tablets contain erythromycin, a macrolide antibiotic. They are used to treat certain infections caused by susceptible bacteria, including mild to moderate respiratory tract and skin infections, as well as whooping cough. Erythromycin works by blocking the production of proteins that susceptible bacteria need.
What it treats
Erythromycin tablets are used for infections caused by susceptible organisms, including: • Certain mild to moderate upper and lower respiratory tract infections, including respiratory infections caused by Mycoplasma pneumoniae. For upper respiratory infections caused by Haemophilus influenzae, treatment requires a sulfonamide antibiotic alongside erythromycin. • Mild to moderate skin and skin structure infections, and erythrasma. • Listeriosis. • Whooping cough (pertussis). • Diphtheria, alongside antitoxin, and elimination of diphtheria bacteria in carriers. • Intestinal amebiasis; infection outside the intestine requires other medicines. • Certain chlamydial infections, including newborn conjunctivitis, infant pneumonia and urogenital infections during pregnancy. • Uncomplicated chlamydial urethral, cervical or rectal infections in adults, and nongonococcal urethritis caused by Ureaplasma urealyticum, when tetracyclines cannot be used or tolerated. • Primary syphilis as an alternative for patients allergic to penicillins. • Legionnaires’ disease, although evidence of effectiveness is limited.
Safety information
Side effects
The most frequent side effects are nausea, vomiting, abdominal pain, diarrhea and loss of appetite. Contact a doctor if you develop symptoms of liver inflammation or liver problems, or severe diarrhea, which may be a sign of pseudomembranous colitis and can occur during or after treatment. Erythromycin has also been associated with changes in the heart’s electrical activity (QT prolongation) and serious abnormal heart rhythms. Seek urgent medical help for a severe allergic reaction, including anaphylaxis, or a severe skin reaction. Allergic reactions can include hives. Rarely reported skin reactions include erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis. Other serious effects reported include kidney inflammation, rare cases of pancreatitis and seizures, and isolated cases of reversible hearing loss, mainly in people with reduced kidney function or those receiving high doses. Contact a doctor if you experience hearing changes or other concerning symptoms.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take erythromycin if you have a known allergy to erythromycin or are taking terfenadine, astemizole, cisapride, pimozide, ergotamine or dihydroergotamine. Do not take erythromycin with lovastatin or simvastatin. These combinations increase the risk of muscle damage, including serious muscle breakdown (rhabdomyolysis).
Interactions
Tell your doctor if you take colchicine, simvastatin, lovastatin, atorvastatin, verapamil, amlodipine or diltiazem. Colchicine taken with erythromycin can cause potentially life-threatening toxicity, even when both medicines are used as prescribed. Simvastatin, lovastatin and atorvastatin can interact with erythromycin and cause serious muscle breakdown (rhabdomyolysis). Verapamil, amlodipine and diltiazem can interact with erythromycin and cause low blood pressure. If lovastatin and erythromycin are used together, your doctor should closely monitor blood tests for muscle injury and liver enzymes.
Using Erythromycin
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label ERYTHROMYCIN TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.] (DailyMed, retrieved 19 September 2026).
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