Differin, illustration of gel tube form (not a photo of the actual pack)

Illustrative image.

Differin

Adapalene

Prescription required

$21.00

0.001 · 1 tube

BrandBranded medicine· By Galderma

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Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.

About Differin

Overview

Differin is a gel containing adapalene, a retinoid medicine. It is used on the skin to treat acne in people aged 12 years and older. Adapalene affects how skin cells develop and how inflammation occurs, although its exact role in treating acne is not fully understood.

What it treats

Acne vulgaris in patients aged 12 years and older.

Safety information

Side effects

Common side effects include skin redness, scaling, dryness, and burning or stinging. Serious allergic reactions can occur, including anaphylaxis, swelling beneath the skin, swelling of the face, eyelids or lips, and itching. Stop using Differin and seek medical help immediately if you have an allergic reaction. Avoid sunlight and sunlamps. Use sunscreen when sun exposure cannot be avoided. Other potentially irritating skin products, including abrasive cleansers, drying soaps or cosmetics, and products high in alcohol, should be used with caution.

When to call your doctor

• Stop using Differin and seek immediate medical attention if you develop swelling of the face, eyelids or lips, which may indicate an allergic reaction.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not use Differin if you are allergic to adapalene or any of its other ingredients. Stop using it if an allergic reaction occurs. Reported reactions include anaphylaxis, swelling of the face, eyelids or lips, and itching. Avoid sunlight and sunlamps. Use sunscreen when sun exposure cannot be avoided. Differin may cause redness, scaling, dryness, stinging or burning. Use caution with other potentially irritating skin products, including medicated or abrasive soaps and cleansers, strongly drying soaps or cosmetics, and products containing high concentrations of alcohol, astringents, spices or lime.

Using Differin

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C with the cap closed, away from direct light and heat. Do not freeze. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.] (DailyMed, retrieved 19 September 2026).

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