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Absorica
Isotretinoin
$60.00
5mg · 3 × 30 capsules · 3 months supply
BrandBranded medicine· By GAP S.A
$20.00 per month
Strength
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Annual cost
$240a year at this pack size
Prescription required
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FDA boxed warningEmbryo-fetal toxicity – contraindicated in pregnancy
ABSORICA/ABSORICA LD can cause life-threatening birth defects and is contraindicated in pregnancy.
There is an extremely high risk that life-threatening birth defects will result if pregnancy occurs while taking any amount of ABSORICA/ABSORICA LD even for short periods of time. Potentially any fetus exposed during pregnancy can be affected. There are no accurate means of determining prenatally whether an exposed fetus has been affected. If pregnancy occurs, discontinue ABSORICA/ABSORICA LD immediately and refer the patient to an Obstetrician- Gynecologist experienced in reproductive toxicity for further evaluation and counseling.
Because of the risk of embryo-fetal toxicity, ABSORICA and ABSORICA LD are available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the iPLEDGE REMS.
ABSORICA/ABSORICA LD are available only through a restricted program called the iPLEDGE ® REMS.
About Absorica
Overview
Absorica capsules contain isotretinoin, a retinoid medicine. It treats severe nodular acne with multiple large, inflamed lumps in non-pregnant patients aged 12 years and older. Because it can cause significant adverse reactions, it is reserved for patients whose acne has not responded to conventional treatments, including oral antibiotics. Its exact action in acne is unknown, but it reduces the activity of the skin’s oil glands and temporarily lowers oil production.
What it treats
Severe nodular acne with multiple inflamed nodules at least 5 mm in diameter in non-pregnant patients aged 12 years and older, when conventional treatments, including systemic antibiotics, have not worked.
Safety information
Side effects
Common side effects include dry, chapped or inflamed lips; dry skin and skin inflammation; dry eyes; back, joint and muscle discomfort; nosebleeds; headache; nose and throat inflammation; upper respiratory tract infections; reduced visual sharpness; and increased blood levels of creatine kinase, a muscle enzyme. Serious side effects include depression, psychosis, suicidal thoughts or behaviour, and aggressive or violent behaviour. Stop taking Absorica and contact a doctor immediately if these occur. Seek emergency help for suicidal thoughts or behaviour. Stop taking Absorica and contact a doctor promptly if you develop a serious skin reaction, symptoms of pancreatitis, abdominal pain, rectal bleeding, severe diarrhoea, hearing problems or changes in vision. Serious skin reactions reported include Stevens–Johnson syndrome and toxic epidermal necrolysis. Vision changes can include reduced night vision, which may persist. Other serious risks include increased pressure inside the skull, liver injury, high blood triglycerides or cholesterol, severe allergic reactions, reduced bone mineral density and premature closure of bone growth plates. Blood fat levels and liver function need monitoring. Taking Absorica with tetracycline antibiotics should be avoided because of the risk of increased pressure inside the skull. Sexual problems, including erectile dysfunction, reduced sex drive and vaginal dryness, have been reported and may continue after treatment stops. Tell your doctor if these occur. Some reported reactions have an uncertain frequency, and their relationship to isotretinoin is not always established.
FDA boxed warning
Embryo-fetal toxicity – contraindicated in pregnancy
ABSORICA/ABSORICA LD can cause life-threatening birth defects and is contraindicated in pregnancy.
There is an extremely high risk that life-threatening birth defects will result if pregnancy occurs while taking any amount of ABSORICA/ABSORICA LD even for short periods of time. Potentially any fetus exposed during pregnancy can be affected. There are no accurate means of determining prenatally whether an exposed fetus has been affected. If pregnancy occurs, discontinue ABSORICA/ABSORICA LD immediately and refer the patient to an Obstetrician- Gynecologist experienced in reproductive toxicity for further evaluation and counseling.
Because of the risk of embryo-fetal toxicity, ABSORICA and ABSORICA LD are available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the iPLEDGE REMS.
ABSORICA/ABSORICA LD are available only through a restricted program called the iPLEDGE ® REMS.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Absorica if you are pregnant or allergic to isotretinoin, vitamin A or any of its ingredients. Breastfeeding is not recommended during treatment. If you can become pregnant, pregnancy testing is required before, during and after treatment, and contraception requirements must be followed. Absorica requires monitoring for depression, psychosis, suicidal thoughts or behaviour, and aggressive or violent behaviour. Stop treatment if these develop. Avoid taking Absorica with tetracycline antibiotics because of the risk of increased pressure inside the skull. Other concerns include serious skin reactions, inflammation of the pancreas, raised blood fats, hearing problems, liver injury, inflammatory bowel disease, joint or back pain, reduced bone density, premature closure of bone growth plates, and vision problems, including reduced night vision. Blood fat levels need regular monitoring, and liver function tests are needed before and during treatment. Treatment must be stopped if raised triglycerides cannot be controlled. Stop treatment and seek medical advice if you develop a serious skin reaction, symptoms of pancreatic inflammation, hearing or vision changes, abdominal pain, rectal bleeding or severe diarrhoea. Hearing and vision changes require specialist assessment.
Interactions
Avoid taking Absorica with vitamin A supplements or tetracycline antibiotics. Tell your doctor if you take either before starting Absorica.
Using Absorica
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label ABSORICA (ISOTRETINOIN) CAPSULE ABSORICA LD (ISOTRETINOIN) CAPSULE [SUN PHARMACEUTICAL INDUSTRIES, INC.] (DailyMed, retrieved 19 September 2026).
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