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Cordarone

Name: Cordarone
Brand: UniPharm
Availability: InStock

Amiodarone

Prescription required

$69.00

200mg · 3 × 30 tablets · 3 months supply

Generic· By UniPharm

$23.00 per month

Brand or generic

Generic packs carry the same active ingredient at the same strength.

How long a supply?

1 month$23.00 a monthOne-off$23.00

3 months$23.00 a monthOne-off$69.00

6 months$23.00 a monthOne-off$138.00

Supplied from Israel

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Annual cost

$276a year at this pack size

Prescription required

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200mg

FDA boxed warningPulmonary, hepatic and cardiac toxicity

BOXED WARNING

Amiodarone hydrochloride is intended for use only in patients with the indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity

Amiodarone hydrochloride can cause pulmonary toxicity (hypersensitivity pneumonitis or interstitial/alveolar pneumonitis) that has resulted in clinically manifest disease at rates as high as 17% in some series of patients. Pulmonary toxicity has been fatal about 10% of the time.

Obtain a baseline chest X-ray and pulmonary-function tests, including diffusion capacity, when amiodarone hydrochloride therapy is initiated. Repeat history, physical exam, and chest X-ray every 3 to 6 months

Amiodarone hydrochloride can cause hepatoxicity, which can be fatal. Obtain baseline and periodic liver transaminases and discontinue or reduce dose if the increase exceeds three times normal, or doubles in a patient with an elevated baseline. Discontinue amiodarone hydrochloride if the patient experiences signs or symptoms of clinical liver injury

Amiodarone hydrochloride can exacerbate arrhythmias. Initiate amiodarone hydrochloride in a clinical setting where continuous electrocardiograms and cardiac resuscitation are available

Reserve amiodarone hydrochloride for patients with the indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity, some also life-threatening. Utilize alternative agents first.

Amiodarone hydrochloride's life-threatening toxicities include pulmonary

, hepatic

, and proarrhythmic

Initiate under hospital or specialist supervision.

Read this with the rest of the clinical information

About Cordarone

Overview

Cordarone contains amiodarone, an antiarrhythmic medicine used to treat certain serious heart rhythm problems in adults. It treats documented, life-threatening episodes of ventricular fibrillation or ventricular tachycardia that recur and disrupt blood circulation. It is reserved for people who have not responded to other antiarrhythmic medicines or cannot tolerate alternatives.

What it treats

- Documented, life-threatening recurrent ventricular fibrillation in adults. - Documented, life-threatening recurrent ventricular tachycardia that causes unstable blood circulation in adults. Used when other antiarrhythmic medicines have not worked adequately or cannot be tolerated.

Safety information

Side effects

Nausea and vomiting are very common side effects. Common side effects include constipation, loss of appetite, abdominal pain, tiredness, dizziness, headache, tremor, tingling, problems with coordination or walking, sleep disturbances, reduced sex drive, changes in taste or smell, flushing, swelling and increased sensitivity to sunlight. Contact a doctor promptly about serious side effects, including: • Lung inflammation or scarring, which can be fatal. Symptoms may include a cough and increasing shortness of breath. • New or worsening heart rhythm problems, a slow heartbeat or heart failure. • Liver injury, which can be life-threatening. Raised liver enzymes may occur without symptoms. • An underactive or overactive thyroid, which can sometimes cause severe complications. • Blurred vision, reduced side vision or other changes in eyesight. Damage or inflammation of the nerve responsible for vision can cause permanent blindness. • Nerve damage, which may cause tingling, numbness or problems with movement and may persist after treatment stops. Severe allergic reactions, including shock and swelling beneath the skin, and severe skin reactions with blistering or peeling have also been reported. These require immediate medical attention. Other serious reports include blood disorders, kidney failure, inflammation of the pancreas and muscle breakdown. The frequency of these reported reactions is unknown, and their relationship to amiodarone cannot always be established. Regular lung, liver, thyroid and eye checks are recommended because some harmful effects may not cause obvious symptoms. Side effects and drug interactions can persist for several weeks after amiodarone is stopped.

FDA boxed warning

Pulmonary, hepatic and cardiac toxicity

BOXED WARNING

Amiodarone hydrochloride is intended for use only in patients with the indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity

Amiodarone hydrochloride can exacerbate arrhythmias. Initiate amiodarone hydrochloride in a clinical setting where continuous electrocardiograms and cardiac resuscitation are available

Amiodarone hydrochloride's life-threatening toxicities include pulmonary

, hepatic

, and proarrhythmic

Initiate under hospital or specialist supervision.

A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.

When to call your doctor

- Seek medical attention immediately for a new cough or worsening shortness of breath. - Get urgent help for new blurred vision, reduced side vision or loss of sight. - Seek immediate care for a new or worsening irregular heartbeat, or a very slow heartbeat. - Get emergency help for swelling of the face, lips or tongue, or difficulty breathing. - Seek immediate care for a severe rash with blistering or peeling skin.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not take Cordarone (amiodarone) if you have cardiogenic shock, or a known allergy to amiodarone or any of its ingredients, including iodine. It must not be used in people with sick sinus syndrome, second- or third-degree heart block, or a slow heartbeat causing fainting, unless they have a functioning pacemaker. Amiodarone can cause serious, sometimes fatal lung or liver injury, worsen abnormal heart rhythms, and cause a very slow heartbeat. Lung assessment, a chest X-ray and liver tests are needed before treatment, with ongoing monitoring. Low potassium, magnesium or calcium must be corrected before treatment. Severe or prolonged diarrhoea and medicines that affect these minerals require particular attention. Thyroid disorders require caution, especially in older adults and people with thyroid nodules, an enlarged thyroid or previous thyroid problems. Thyroid testing is needed before and during treatment. Regular eye examinations are recommended because amiodarone can damage the optic nerve and sometimes cause permanent blindness. Changes in eyesight require prompt assessment. People with a pacemaker or implanted defibrillator need device checks before and during treatment. Other medicines that slow the heart, including certain heart rhythm medicines, can increase the risk of a slow heartbeat. Serious slowing of the heart has also been reported with ledipasvir/sofosbuvir or sofosbuvir with simeprevir. Surgery requires caution because amiodarone can increase sensitivity to certain anaesthetics, and severe breathing problems have been reported after surgery. Amiodarone may harm an unborn baby. Breastfeeding is not recommended during treatment. Animal studies suggest it may reduce fertility in males and females; whether this is reversible is unknown. Safety and effectiveness in children have not been established. Older adults require particular caution because the medicine is cleared more slowly. Long-term treatment can cause nerve damage that may persist after stopping, increased sensitivity to sunlight and blue-grey skin discolouration. Side effects and medicine interactions can continue for several weeks after treatment ends.

Interactions

Amiodarone interactions can persist for weeks to months after treatment stops. Avoid grapefruit juice and medicines that prolong the QT interval, an electrical timing measure of the heart, because of increased amiodarone levels or a risk of a dangerous heart rhythm. These medicines include certain other heart rhythm medicines, lithium, some antidepressants and antipsychotics, certain fluoroquinolone and macrolide antibiotics, azole antifungals and some inhaled anaesthetics. Cimetidine and certain protease inhibitors can also increase amiodarone levels and should not be used together with it. Other important interactions to raise with your doctor include: • Digoxin, beta blockers, verapamil, diltiazem, clonidine and ivabradine: may cause an excessively slow heartbeat or block electrical signals in the heart. Heart rate monitoring is needed. Amiodarone also increases digoxin levels. • Warfarin: its blood-thinning effect can increase, causing serious or fatal bleeding. Blood-clotting tests need monitoring. • Simvastatin, lovastatin and atorvastatin: their levels can increase. • Cyclosporine: levels can increase and kidney function may be affected. Drug levels and kidney function need monitoring. • Phenytoin: levels can increase and need monitoring. • Sofosbuvir: a slow, symptomatic heart rhythm requiring a pacemaker has been reported with this combination. • Lidocaine used for local anaesthesia: may slow the heartbeat; heart rate monitoring is needed. • Fentanyl: may cause low blood pressure, a slow heartbeat and reduced blood flow from the heart. • St. John’s wort and cholestyramine: can lower amiodarone levels. Other heart rhythm medicines, including quinidine, procainamide and flecainide, require careful specialist monitoring if combined with amiodarone. The label reserves these combinations for patients who have not responded to a single medicine.

Using Cordarone

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label AMIODARONE HYDROCHLORIDE TABLET [REMEDYREPACK INC.] (DailyMed, retrieved 19 September 2026).

Patient information and references

Official and supporting information to read alongside advice from your prescriber or pharmacist.

Patient information leaflet (PDF)

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