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Colcrys
Colchicine
$123.00
0.5mg · 3 × 30 tablets · 3 months supply
GenericGeneric medicine· By Rafa
$41.00 per month
How long a supply?
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Annual cost
$492a year at this pack size
Prescription required
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About Colcrys
Overview
Colcrys is a prescription medicine containing colchicine. It is used to prevent and treat gout flares in adults and to treat familial Mediterranean fever (FMF) in adults and children aged 4 years and older. It works by interfering with the activity and movement of certain white blood cells involved in gout inflammation, although how it helps FMF is not fully understood. Colcrys is not a general pain reliever and should not be used for pain from other causes.
What it treats
- Prevention and treatment of gout flares in adults. - Familial Mediterranean fever (FMF) in adults and children aged 4 years and older.
Safety information
Side effects
Common side effects include diarrhea. Pain in the throat was also reported during treatment of gout flares. In people taking Colcrys for familial Mediterranean fever (FMF), common side effects include abdominal pain, diarrhea, nausea and vomiting. Serious side effects that warrant contacting a doctor include blood disorders, such as reduced production of blood cells, low white blood cell or platelet counts, and aplastic anemia. Muscle toxicity, including severe muscle breakdown (rhabdomyolysis), can also occur, especially when Colcrys is combined with other medicines that can damage muscles. Taking colchicine with medicines that inhibit P-gp or strongly inhibit CYP3A4 can cause life-threatening interactions and death. Colchicine overdoses have been fatal in adults and children.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Colcrys if you have kidney or liver impairment and are also taking a P-glycoprotein (P-gp) inhibitor or a strong CYP3A4 inhibitor. The label includes all protease inhibitors except fosamprenavir in this restriction. These combinations have caused life-threatening and fatal colchicine toxicity, even at prescribed doses. Caution and close monitoring are needed in people with kidney or liver impairment, including those undergoing dialysis. Kidney function is particularly important in older adults. P-gp or strong CYP3A4 inhibitors can also cause life-threatening interactions in other patients. Colchicine can cause serious blood disorders and muscle damage, including rhabdomyolysis. Muscle toxicity may be more likely when taken with other medicines that can also damage muscles. Treatment may need to be interrupted or stopped if toxicity develops. During pregnancy, use only if the potential benefit justifies the potential risk to the fetus. Caution is required while breastfeeding. Overdose can be fatal in adults and children.
Interactions
Some medicines can increase colchicine levels in the body and cause serious toxicity. Fatal interactions have been reported. Tell your doctor if you take clarithromycin, cyclosporine or other medicines that block P-glycoprotein (P-gp) or CYP3A4. Also raise any use of cholesterol-lowering medicines, including atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin, fibrates or gemfibrozil, and the heart medicine digoxin. These combinations may cause muscle damage, including severe muscle breakdown (rhabdomyolysis). Report muscle pain, tenderness or weakness promptly, particularly when starting a combination. Your doctor should check for interactions before and during treatment. Suspected colchicine toxicity needs prompt assessment and immediate discontinuation of Colcrys.
Using Colcrys
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label COLCRYS (COLCHICINE) TABLET, FILM COATED [PROFICIENT RX LP] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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