Cholbam, illustration of capsule form (not a photo of the actual pack)

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Cholbam

Cholic Acid

Prescription required

$15025.00

50mg · 90 capsules

BrandBranded medicine· By Patheon

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50mg

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About Cholbam

Overview

Cholbam is a prescription medicine containing cholic acid, a bile acid, in capsules. It treats bile acid synthesis disorders caused by single enzyme defects. It is also used as an add-on treatment for peroxisomal disorders, including Zellweger spectrum disorders, in patients with signs of liver disease, fatty stools or complications from reduced absorption of fat-soluble vitamins. Cholic acid helps bile flow, fat digestion and vitamin absorption, although its exact role in treating these disorders is not fully understood.

What it treats

- Bile acid synthesis disorders caused by single enzyme defects. - As an additional treatment for peroxisomal disorders, including Zellweger spectrum disorders, in patients with signs of liver disease, fatty stools, or complications from reduced absorption of fat-soluble vitamins. Safety and effectiveness for manifestations of these disorders outside the liver have not been established.

Safety information

Side effects

Common side effects include diarrhea, inflammation of the food pipe caused by acid reflux, feeling generally unwell, jaundice (yellowing of the skin or eyes), skin lesions, nausea, abdominal pain, intestinal polyps, urinary tract infections, and peripheral nerve problems. Cholbam can worsen liver impairment. Contact your doctor if you develop jaundice or are told that your liver function has worsened. Liver function must be monitored during treatment, and Cholbam must be discontinued if it worsens.

When to call your doctor

• Seek medical attention immediately if your skin or the whites of your eyes turn yellow (jaundice), as Cholbam can worsen liver problems.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

The label lists no contraindications to Cholbam. However, liver impairment may worsen during treatment. Liver function must be monitored, and Cholbam must be discontinued if liver function worsens.

Interactions

Tell your doctor if you take cyclosporine or another bile salt efflux pump (BSEP) inhibitor. Use with Cholbam should be avoided. If both are necessary, your doctor should monitor liver enzymes and bilirubin through blood tests. Bile acid binding resins and aluminum-based antacids must be taken separately from Cholbam. Ask your doctor how to space these medicines apart.

Using Cholbam

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label CHOLBAM (CHOLIC ACID) CAPSULE [MIRUM PHARMACEUTICALS INC.] (DailyMed, retrieved 19 September 2026).

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