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Caprelsa
Vandetanib
$10335.00
100mg · 3 × 30 tablets · 3 months supply
BrandBranded medicine· By Sanofi
$3445.00 per month
How long a supply?
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Annual cost
$41340a year at this pack size
Prescription required
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FDA boxed warningQt prolongation, torsades de pointes, and sudden death
CAPRELSA can prolong the QT interval. Torsades de pointes and sudden death have occurred in patients receiving CAPRELSA. Do not use CAPRELSA in patients with hypocalcemia, hypokalemia, hypomagnesemia, or long QT syndrome. Correct hypocalcemia, hypokalemia and/or hypomagnesemia prior to CAPRELSA administration. Monitor electrolytes periodically. Avoid drugs known to prolong the QT interval.
About Caprelsa
Overview
Caprelsa contains vandetanib, a medicine called a kinase inhibitor. It treats medullary thyroid cancer that is causing symptoms or progressing and is locally advanced and cannot be removed by surgery, or has spread to other parts of the body. Laboratory studies show that vandetanib blocks proteins involved in cancer growth and the formation of blood vessels that supply tumours. For disease that is not causing symptoms or is slow-growing, its treatment risks must be carefully considered before use.
What it treats
Medullary thyroid cancer that is causing symptoms or progressing and is locally advanced and cannot be removed surgically, or has spread to other parts of the body. Use in slow-growing disease or disease without symptoms requires careful consideration of treatment-related risks.
Safety information
Side effects
Common side effects of Caprelsa include diarrhea or inflammation of the colon, rash, acne-like skin reactions, high blood pressure, nausea, headache, upper respiratory tract infections, reduced appetite and abdominal pain. Serious side effects require prompt medical attention. These include changes in the heart’s electrical activity (QT prolongation), dangerous heart rhythms, severe skin reactions, inflammation of the lungs, stroke caused by reduced blood flow, bleeding, heart failure, diarrhea, high blood pressure, an underactive thyroid and kidney failure. Other serious risks include a brain condition called reversible posterior leukoencephalopathy syndrome and death of bone tissue, including in the jaw. Heart rhythm problems can cause sudden death, and severe skin and lung reactions can be fatal. Caprelsa can also impair wound healing and harm an unborn baby. Tell your doctor about planned surgery or dental surgery, or if you are pregnant or could become pregnant. Women who could become pregnant should use effective contraception. Treatment requires monitoring of heart rhythm, blood minerals and thyroid function.
FDA boxed warning
Qt prolongation, torsades de pointes, and sudden death
CAPRELSA can prolong the QT interval. Torsades de pointes and sudden death have occurred in patients receiving CAPRELSA. Do not use CAPRELSA in patients with hypocalcemia, hypokalemia, hypomagnesemia, or long QT syndrome. Correct hypocalcemia, hypokalemia and/or hypomagnesemia prior to CAPRELSA administration. Monitor electrolytes periodically. Avoid drugs known to prolong the QT interval.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Caprelsa if you have congenital long QT syndrome, an inherited heart rhythm condition. Caprelsa can prolong the heart’s QT interval and cause a dangerous abnormal rhythm called torsades de pointes or sudden death. Monitoring includes electrocardiograms (ECGs) and blood tests for potassium, calcium, magnesium and thyroid-stimulating hormone (TSH). Other serious risks include severe skin reactions, sometimes fatal; interstitial lung disease, which can be fatal; stroke caused by reduced blood flow; bleeding; heart failure; diarrhoea; high blood pressure; and reversible posterior leukoencephalopathy syndrome, a brain condition. Unexplained breathing symptoms need investigation. Treatment may need to be interrupted or stopped if serious problems occur. Caprelsa can impair wound healing and cause bone damage, including in the jaw. Tell your prescriber about planned surgery or dental surgery, as treatment must be withheld around these procedures. Treatment must be permanently stopped if osteonecrosis occurs. Caprelsa can harm an unborn baby. Women who could become pregnant should use effective contraception.
Interactions
Avoid taking Caprelsa with strong CYP3A4 inducers, which can reduce the amount of Caprelsa in the body, or with medicines that prolong the QT interval, a measure of the heart’s electrical activity. Ask your doctor to check whether any medicines you take fall into these groups.
Using Caprelsa
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label CAPRELSA (VANDETANIB) TABLET, FILM COATED [GENZYME CORPORATION] (DailyMed, retrieved 19 September 2026).
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