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Trilafon

Name: Trilafon
Brand: Taro
Availability: InStock

Perphenazine

Prescription required

$68.00

8mg · 4 × 20 tablets · 1 month supply

GenericGeneric medicine· By Taro

$68.00 per month

Strength

How long a supply?

1 month$68.00 a monthOne-off$68.00

Supplied from Israel

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Annual cost

$884a year at this pack size

Prescription required

Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.

4mg

8mg

FDA boxed warning

WARNING

Increased Mortality in Elderly Patients with Dementia-Related Psychosis

Elderly patients with dementia-related psychosis treated with antipsychotic drugs

are at an increased risk of death. Analyses of seventeen placebo-controlled trials

(modal duration of 10 weeks), largely in patients taking atypical antipsychotic

drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times

the risk of death in placebo-treated patients. Over the course of a typical 10-week

controlled trial, the rate of death in drug-treated patients was about 4.5%,

compared to a rate of about 2.6% in the placebo group. Although the causes of

death were varied, most of the deaths appeared to be either cardiovascular (e.g.,

heart failure, sudden death) or infectious (e.g., pneumonia) in nature.

Observational studies suggest that, similar to atypical antipsychotic drugs,

treatment with conventional antipsychotic drugs may increase mortality. The

extent to which the findings of increased mortality in observational studies may be

attributed to the antipsychotic drug as opposed to some characteristic(s) of the

patients is not clear. Perphenazine is not approved for the treatment of patients

Read this with the rest of the clinical information

About Trilafon

Overview

Trilafon contains perphenazine, a phenothiazine medicine supplied as tablets. It is used to treat schizophrenia and to control severe nausea and vomiting in adults. Perphenazine acts throughout the central nervous system, but exactly how it produces its treatment effects is not known.

What it treats

- Schizophrenia - Severe nausea and vomiting in adults

Safety information

Side effects

Movement-related side effects are more common with perphenazine and related medicines than some other side effects. These include restlessness, muscle stiffness or spasms, tremor-like movements, and problems with coordination. Drowsiness may occur, especially during the first two weeks. Other possible effects include dry mouth or increased saliva, constipation, nausea, vomiting, diarrhea, blurred vision, dizziness, headache, sleep difficulties, and changes in appetite or weight. Changes in menstrual periods, breast enlargement, milk production and sexual function may also occur. Contact a doctor promptly for involuntary movements of the tongue, face, mouth, jaw or limbs. These may be signs of tardive dyskinesia, which can persist and may be irreversible, even after treatment stops. Other movement problems can also continue after stopping treatment. A sudden sore throat or other signs of infection need prompt medical review because serious blood-cell disorders can occur. Yellowing of the skin or eyes may indicate liver damage. Difficulty passing urine, severe constipation, fainting, changes in heart rate, or new or worsening mental or behavioral symptoms also require medical attention. Seek urgent medical help for muscle spasms involving the throat, difficulty swallowing or breathing, swelling of the face or throat, or seizures. Serious reported reactions also include severe allergic reactions, bowel paralysis, cardiac arrest and neuroleptic malignant syndrome. Sudden deaths have been reported with this medicine class, although a link to the medicine could not always be established. The label includes reactions reported with related phenothiazine medicines; not all have been reported specifically with perphenazine.