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Propylthiouracil
Propylthiouracil
$225.00
50mg · 9 × 30 tablets · 3 months supply
GenericGeneric medicine· By Teva
$75.00 per month
How long a supply?
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Annual cost
$925a year at this pack size
Prescription required
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FDA boxed warning
WARNING
Severe liver injury and acute liver failure, in some cases fatal, have been reported in patients treated with propylthiouracil. These reports of hepatic reactions include cases requiring liver transplantation in adult and pediatric patients.
Propylthiouracil should be reserved for patients who cannot tolerate methimazole and in whom radioactive iodine therapy or surgery are not appropriate treatments for the management of hyperthyroidism.
Propylthiouracil may be the treatment of choice when an antithyroid drug is indicated during or just prior to the first trimester of pregnancy
(see
Warnings
and
Precautions).
About Propylthiouracil
Overview
Propylthiouracil is an antithyroid medicine taken as a tablet. It treats an overactive thyroid caused by Graves’ disease or toxic multinodular goiter when methimazole cannot be tolerated and surgery or radioactive iodine treatment is not appropriate. It can also help relieve overactive thyroid symptoms before thyroid surgery or radioactive iodine treatment in people who cannot tolerate methimazole.
What it treats
- Hyperthyroidism due to Graves’ disease or toxic multinodular goiter when methimazole is not tolerated and surgery or radioactive iodine therapy is not appropriate. - Relief of hyperthyroidism symptoms before thyroid surgery or radioactive iodine therapy when methimazole is not tolerated.
Safety information
Side effects
Reported side effects include rash, hives, itching, nausea, vomiting, upper abdominal discomfort, joint or muscle pain, headache, drowsiness, dizziness, tingling, changes in or loss of taste, hair loss, swelling, changes in skin colour, and swollen salivary glands or lymph nodes. Their frequency cannot be reliably estimated from the available reports. Serious reported side effects that warrant contacting a doctor include liver inflammation or liver failure, which has required transplantation or caused death; yellowing of the skin or eyes (jaundice); reduced production of blood cells, including severe loss of certain white blood cells, anaemia or low platelets; and impaired blood clotting or bleeding. Other serious reactions include inflammation of blood vessels, which has caused severe complications and death; a lupus-like illness; kidney or lung inflammation; drug-related fever; and severe skin reactions, including peeling skin, Stevens–Johnson syndrome and toxic epidermal necrolysis.
FDA boxed warning
WARNING
Severe liver injury and acute liver failure, in some cases fatal, have been reported in patients treated with propylthiouracil. These reports of hepatic reactions include cases requiring liver transplantation in adult and pediatric patients.
Propylthiouracil should be reserved for patients who cannot tolerate methimazole and in whom radioactive iodine therapy or surgery are not appropriate treatments for the management of hyperthyroidism.
Propylthiouracil may be the treatment of choice when an antithyroid drug is indicated during or just prior to the first trimester of pregnancy
(see
Warnings
and
Precautions).
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take propylthiouracil if you are allergic to propylthiouracil or any other ingredient in the tablets.
Interactions
Tell your doctor if you take any of the following: - Oral blood thinners, such as warfarin: propylthiouracil may increase their effect. Extra blood-clotting tests (PT/INR) may be needed, especially before surgery. - Beta blockers: as thyroid function returns to normal, your doctor may need to adjust your treatment. - Digitalis medicines: blood levels may rise as thyroid function returns to normal, so your doctor may need to adjust your treatment. - Theophylline: your body may clear it more slowly as thyroid function returns to normal, so your doctor may need to adjust your treatment.
Using Propylthiouracil
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label PROPYLTHIOURACIL TABLET [PAR HEALTH USA, LLC] (DailyMed, retrieved 19 September 2026).
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