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Prometrium
Progesterone Micronized
$93.00
100mg · 3 × 30 capsules · 3 months supply
Generic· By Besins
$31.00 per month
Brand or generic
Generic packs carry the same active ingredient at the same strength.
Strength
How long a supply?
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Annual cost
$372a year at this pack size
Prescription required
Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.
100mg
200 mg
FDA boxed warning
WARNINGS Progestins and estrogens should not be used for the prevention of
cardiovascular disease. (See
WARNINGS,
Cardiovascular Disorders
The Women's Health Initiative (WHI) study reported increased risks of
myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and
deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5
years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with
medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (See
CLINICAL PHARMACOLOGY, Clinical
Studies
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI,
reported increased risk of developing probable dementia in postmenopausal women
65 years of age or older during 4 years of treatment with oral conjugated
estrogens plus medroxyprogesterone acetate relative to placebo. It is unknown
whether this finding applies to younger postmenopausal women. (See
Other doses of oral conjugated estrogens with medroxyprogesterone and other
combinations and dosage forms of estrogens and progestins were not studied in
the WHI clinical trials. In the absence of comparable data and product-specific
established. Therefore, the risks should be assumed to be similar for all
estrogen and progestin products. Because of these risks, estrogens with or
without progestins should be prescribed at the lowest effective doses and for
the shortest duration consistent with treatment goals and risks for the
individual woman.
About Prometrium
Overview
Prometrium is an oral capsule containing micronized progesterone. It is used to help prevent excessive thickening of the uterine lining in postmenopausal women who still have a uterus and are taking conjugated estrogen tablets. It is also used to treat secondary amenorrhea, when menstrual periods stop after previously occurring. It supplies progesterone that is chemically identical to the progesterone made by the human ovaries.
What it treats
- Prevention of endometrial hyperplasia (overgrowth of the uterine lining) in postmenopausal women who have a uterus and are taking conjugated estrogen tablets. - Secondary amenorrhea (absence of menstrual periods after previously having them).
Safety information
Side effects
Commonly reported side effects of Prometrium capsules include dizziness, headache, breast pain or tenderness, stomach pain or cramps, bloating, tiredness, muscle or joint pain, mood changes and irritability. Nausea, vomiting, diarrhea and depression have also been reported. Contact a doctor promptly for chest pain, a fast or pounding heartbeat, unusual or heavy vaginal bleeding, vision changes, or yellowing of the skin or eyes. Serious reports include liver injury or liver failure, inflammation of the pancreas, and cancer of the uterine lining. Breast cancer was reported in a trial of Prometrium taken with estrogen. Seek immediate medical help for difficulty breathing, throat tightness, swelling of the face or tongue, seizures, loss of consciousness, difficulty speaking, or thoughts of suicide. Severe allergic reactions and transient ischemic attacks (temporary interruptions of blood flow to the brain) have been reported. These events were reported during clinical trials or after marketing; a report does not necessarily mean Prometrium caused the event.
FDA boxed warning
WARNINGS Progestins and estrogens should not be used for the prevention of
cardiovascular disease. (See
WARNINGS,
Cardiovascular Disorders
The Women's Health Initiative (WHI) study reported increased risks of
myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and
deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5
years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with
medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (See
CLINICAL PHARMACOLOGY, Clinical
Studies
The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI,
reported increased risk of developing probable dementia in postmenopausal women
65 years of age or older during 4 years of treatment with oral conjugated
estrogens plus medroxyprogesterone acetate relative to placebo. It is unknown
whether this finding applies to younger postmenopausal women. (See
Other doses of oral conjugated estrogens with medroxyprogesterone and other
combinations and dosage forms of estrogens and progestins were not studied in
the WHI clinical trials. In the absence of comparable data and product-specific
established. Therefore, the risks should be assumed to be similar for all
estrogen and progestin products. Because of these risks, estrogens with or
without progestins should be prescribed at the lowest effective doses and for
the shortest duration consistent with treatment goals and risks for the
individual woman.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Prometrium capsules if you have: • An allergy to peanuts or any ingredient in the capsules. Prometrium contains peanut oil. • Abnormal genital bleeding that has not been diagnosed. • Known or suspected breast cancer, or a history of breast cancer. • A current or previous deep vein thrombosis (blood clot in a deep vein) or pulmonary embolism (blood clot in the lungs). • Current or recent disease caused by a blood clot in an artery, such as a stroke or heart attack, including within the past year. • Liver disease or impaired liver function. • Known or suspected pregnancy. Prometrium is not indicated for use during pregnancy.
Using Prometrium
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label PROMETRIUM (PROGESTERONE) CAPSULE [PHYSICIANS TOTAL CARE, INC.] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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