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Pramin
Metoclopramide
$154.00
10mg · 11 × 30 tablets · 3 months supply
GenericGeneric medicine· By Rafa
$51.33 per month
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Annual cost
$644a year at this pack size
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FDA boxed warningTardive dyskinesia
Metoclopramide, including metoclopramide tablets, can cause tardive dyskinesia (TD), a potentially irreversible serious movement disorder. In patients treated with metoclopramide, including metoclopramide tablets, the risk of developing TD increases with duration of treatment and total cumulative dosage
Metoclopramide tablets are contraindicated in patients with a history of TD.
Use metoclopramide tablets for the shortest duration of treatment and periodically reassess the need for continued treatment.
Immediately discontinue metoclopramide tablets in patients who develop signs or symptoms of TD
In patients with symptomatic, documented gastroesophageal reflux, the maximum duration of metoclopramide tablets treatment is 12 weeks
In patients with diabetic gastroparesis, avoid a total duration of treatment with metoclopramide products, including metoclopramide tablets, for longer than 12 weeks. If longer term use is unavoidable, routinely monitor for signs and symptoms of TD
Metoclopramide, including metoclopramide tablets, can cause tardive dyskinesia (TD), a potentially irreversible serious movement disorder. In patients treated with metoclopramide, including metoclopramide tablets, the risk of developing TD increases with duration of metoclopramide treatment and total cumulative metoclopramide dosage.
In patients with symptomatic, documented gastroesophageal reflux, the maximum duration of treatment is 12 weeks.
About Pramin
Overview
Pramin is a prescription medicine containing metoclopramide. It is used in adults to treat symptomatic, documented gastroesophageal reflux that has not responded to conventional treatment. It also relieves symptoms of acute and recurrent diabetic gastroparesis, a condition involving delayed stomach emptying. It works by increasing movement in the upper digestive tract, helping the stomach empty faster and tightening the muscle between the stomach and esophagus.
What it treats
- Symptomatic, documented gastroesophageal reflux in adults who have not responded to conventional treatment, for short-term treatment of 4 to 12 weeks. - Symptoms of acute and recurrent diabetic gastroparesis in adults.
Safety information
Side effects
Common side effects include restlessness, drowsiness, tiredness and lack of energy. Other reported effects include diarrhea, nausea, headache, dizziness, trouble sleeping and confusion. Drowsiness may affect your ability to drive or operate machinery. Stop taking metoclopramide and seek immediate medical attention if you develop involuntary movements (tardive dyskinesia), muscle spasms, Parkinson-like movement problems or neuroleptic malignant syndrome. Seek urgent medical attention for seizures, depression or suicidal thoughts, hallucinations, or allergic reactions such as wheezing or swelling of the tongue or throat. Other serious reported effects include heart failure, changes in blood pressure or heartbeat, fluid retention, blood disorders and liver injury, including jaundice. Serotonin syndrome has been reported when metoclopramide is taken with medicines that affect serotonin. Contact your doctor about vision changes, urinary problems, unexpected breast milk production, missed periods, breast enlargement or impotence. Dizziness, nervousness and headaches have also occurred after stopping metoclopramide.
FDA boxed warning
Tardive dyskinesia
Metoclopramide, including metoclopramide tablets, can cause tardive dyskinesia (TD), a potentially irreversible serious movement disorder. In patients treated with metoclopramide, including metoclopramide tablets, the risk of developing TD increases with duration of treatment and total cumulative dosage
Metoclopramide tablets are contraindicated in patients with a history of TD.
Use metoclopramide tablets for the shortest duration of treatment and periodically reassess the need for continued treatment.
Immediately discontinue metoclopramide tablets in patients who develop signs or symptoms of TD
In patients with symptomatic, documented gastroesophageal reflux, the maximum duration of metoclopramide tablets treatment is 12 weeks
In patients with diabetic gastroparesis, avoid a total duration of treatment with metoclopramide products, including metoclopramide tablets, for longer than 12 weeks. If longer term use is unavoidable, routinely monitor for signs and symptoms of TD
Metoclopramide, including metoclopramide tablets, can cause tardive dyskinesia (TD), a potentially irreversible serious movement disorder. In patients treated with metoclopramide, including metoclopramide tablets, the risk of developing TD increases with duration of metoclopramide treatment and total cumulative metoclopramide dosage.
In patients with symptomatic, documented gastroesophageal reflux, the maximum duration of treatment is 12 weeks.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Pramin (metoclopramide) if you: • Have a history of tardive dyskinesia (involuntary movements) or have had a dystonic reaction (abnormal muscle contractions) to metoclopramide. • Have bleeding, a mechanical blockage or a perforation in the digestive tract, or another condition where stimulating gut movement could be dangerous. • Have a pheochromocytoma or another catecholamine-releasing paraganglioma, as metoclopramide may trigger a dangerous rise in blood pressure. • Have epilepsy, as metoclopramide may increase the frequency and severity of seizures. • Are allergic to metoclopramide. Reported reactions include swelling of the tongue or throat and narrowing of the airways. Use should be avoided in people with Parkinson’s disease or depression because of the warnings about movement disorders and suicidal thoughts or suicide. Avoid taking metoclopramide with other medicines known to cause tardive dyskinesia, other drug-induced movement disorders or neuroleptic malignant syndrome. If symptoms of these movement disorders or neuroleptic malignant syndrome occur, stop taking metoclopramide and seek immediate medical attention.
Interactions
Tell your doctor if you take any of the following before using Pramin (metoclopramide): • Antipsychotics: Use together should be avoided because it can increase the risk of movement disorders, including tardive dyskinesia, and neuroleptic malignant syndrome. • Central nervous system depressants: Use together should be avoided because it increases the risk of reduced alertness and other effects on the central nervous system. Monitoring for adverse reactions is needed. • Strong CYP2D6 inhibitors, such as quinidine, bupropion, fluoxetine or paroxetine: Your prescriber may need to reduce your metoclopramide dose. • Monoamine oxidase (MAO) inhibitors: Use together should be avoided because it increases the risk of high blood pressure.
Using Pramin
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label METOCLOPRAMIDE TABLET [REMEDYREPACK INC.] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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