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Ozempic
Semaglutide
$747.00
0.25mg · 3 × 1 pen · 3 months supply
BrandBranded medicine· By NovoNordisk
$249.00 per month
Strength
How long a supply?
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Annual cost
$3237a year at this pack size
Prescription required
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0.25mg
0.5mg
1mg
FDA boxed warningRisk of thyroid c-cell tumors
In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether OZEMPIC causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined.
OZEMPIC is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk for MTC with the use of OZEMPIC and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with OZEMPIC.
In rodents, semaglutide causes thyroid C-cell tumors. It is unknown whether OZEMPIC causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined.
OZEMPIC is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk of MTC and symptoms of thyroid tumors.
About Ozempic
Overview
Ozempic contains semaglutide, a GLP-1 receptor agonist given by injection under the skin. It is used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes. It also reduces the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, and of sustained kidney function decline, end-stage kidney disease and cardiovascular death in adults with type 2 diabetes and chronic kidney disease. It lowers blood sugar by helping the body release insulin and reducing glucagon release when blood sugar is high.
What it treats
• To improve blood sugar control in adults with type 2 diabetes, alongside diet and exercise. • To reduce the risk of cardiovascular death, non-fatal heart attack or non-fatal stroke in adults with type 2 diabetes and established cardiovascular disease. • To reduce the risk of sustained kidney function decline, end-stage kidney disease and cardiovascular death in adults with type 2 diabetes and chronic kidney disease.
Safety information
Side effects
Common side effects of Ozempic include nausea, vomiting, diarrhoea, abdominal pain and constipation. Other reported effects include indigestion, burping, gas, acid reflux, stomach inflammation, tiredness, dizziness, changes in taste and discomfort or redness at the injection site. Serious side effects and risks include: • Inflammation of the pancreas (pancreatitis), which can be fatal. Persistent or severe abdominal pain, sometimes spreading to the back, with or without nausea or vomiting, needs prompt medical attention. Stop Ozempic if pancreatitis is suspected. • Serious allergic reactions, including anaphylaxis and swelling beneath the skin (angioedema). Stop Ozempic and seek medical help immediately if a serious allergic reaction is suspected. • Low blood sugar, including severe episodes, when used with insulin or medicines that increase insulin release, such as sulfonylureas. Discuss this risk with your prescriber. • Kidney injury, sometimes requiring dialysis, associated with dehydration from nausea, vomiting or diarrhoea. Contact your doctor if these effects persist or lead to dehydration. • Severe digestive problems. Bowel blockage and severe constipation, including impacted stool, have been reported. Contact your doctor for severe digestive symptoms. Ozempic is not recommended for people with severely delayed stomach emptying (gastroparesis). • Complications of diabetes-related eye disease (diabetic retinopathy). People with a history of this condition should be monitored for worsening. • Gallbladder problems, including gallstones and inflammation, which require medical assessment if suspected. • A possible risk of thyroid C-cell tumours. Semaglutide caused these tumours in rodents; it is not known whether it causes them in humans. Contact your doctor if you develop a neck lump, difficulty swallowing or breathing, or persistent hoarseness. Do not use Ozempic if you or a family member has had medullary thyroid cancer, or if you have multiple endocrine neoplasia syndrome type 2 (MEN 2). • Stomach contents entering the lungs during general anaesthesia or deep sedation. Tell your healthcare team that you use Ozempic before any planned surgery or procedure. Some serious reactions were reported after semaglutide became available for use. Their frequency and whether semaglutide caused them cannot always be established.
FDA boxed warning
Risk of thyroid c-cell tumors
In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures. It is unknown whether OZEMPIC causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined.
OZEMPIC is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk for MTC with the use of OZEMPIC and inform them of symptoms of thyroid tumors (e.g., a mass in the neck, dysphagia, dyspnea, persistent hoarseness). Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with OZEMPIC.
In rodents, semaglutide causes thyroid C-cell tumors. It is unknown whether OZEMPIC causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans as the human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined.
OZEMPIC is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk of MTC and symptoms of thyroid tumors.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not use Ozempic if you or a family member has had medullary thyroid carcinoma (MTC), if you have multiple endocrine neoplasia syndrome type 2 (MEN 2), or if you have had a serious allergic reaction to semaglutide or any other ingredient in Ozempic. Semaglutide caused thyroid C-cell tumours in rodents; whether it causes these tumours in humans is unknown. Report a neck lump, difficulty swallowing or breathing, or persistent hoarseness to your healthcare professional. Ozempic is not recommended for people with severe gastroparesis (severely delayed stomach emptying). Other conditions requiring caution include: • Diabetic retinopathy: existing diabetes-related eye disease should be monitored for worsening. • Use of insulin or medicines that stimulate insulin release, such as sulfonylureas: the risk of low blood sugar, including severe episodes, is increased. • Nausea, vomiting or diarrhoea causing dehydration: this can lead to acute kidney injury, and kidney function may need monitoring. • Previous serious allergic reactions to another GLP-1 receptor agonist: caution is needed because the risk of a similar reaction with Ozempic is unknown. Stop using Ozempic and seek prompt medical care if pancreatitis or a serious allergic reaction is suspected. Pancreatitis may cause persistent or severe abdominal pain, sometimes spreading to the back, with or without nausea or vomiting. Suspected gallstones or gallbladder inflammation require assessment. Tell your healthcare team about any planned surgery or procedure. Aspiration of stomach contents into the lungs has been reported during general anaesthesia or deep sedation in people receiving GLP-1 receptor agonists. Ozempic should be stopped at least two months before a planned pregnancy. Never share an Ozempic pen, even if the needle is changed, because this can transmit blood-borne infections.
Interactions
Using Ozempic with insulin or medicines that stimulate insulin release, such as sulfonylureas, can increase the risk of low blood sugar, including severe episodes. Tell your doctor if you take these medicines; they may need to adjust your treatment to reduce this risk. Ozempic slows stomach emptying, which may affect how medicines taken by mouth are absorbed. Clinical studies did not find a clinically relevant effect on absorption, but the label still advises caution. Let your doctor know which oral medicines you take.
Using Ozempic
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use and how long it may be kept at room temperature afterwards. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label OZEMPIC (SEMAGLUTIDE) INJECTION, SOLUTION [A-S MEDICATION SOLUTIONS] (DailyMed, retrieved 19 September 2026).
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