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Nexium

Name: Nexium
Brand: Astra Zeneca
Availability: InStock

Esomeprazole

Prescription required

$69.00

20 mg · 3 × 28 tablets · 3 months supply

BrandBranded medicine· By Astra Zeneca

$23.00 per month

Strength

How long a supply?

1 month$23.00 a monthOne-off$23.00

3 months$23.00 a monthOne-off$69.00

6 months$23.00 a monthOne-off$138.00

Supplied from Israel

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Annual cost

$299a year at this pack size

Prescription required

Upload your prescription after ordering, or send it to our pharmacy team. We dispense only against a valid prescription.

20 mg

40 mg

About Nexium

Overview

Nexium contains esomeprazole, a proton pump inhibitor (PPI). It is used for short-term treatment of heartburn and other symptoms of gastroesophageal reflux disease (GERD), to heal acid-related damage to the esophagus, and to maintain healing in adults. In adults, it is also used to reduce the risk of stomach ulcers associated with NSAIDs in people at risk, alongside antibiotics to eradicate H. pylori and reduce duodenal ulcer recurrence, and to treat conditions that cause excessive stomach acid. It works by blocking the acid pumps in the stomach lining, reducing acid production.

What it treats

- Short-term treatment to heal erosive esophagitis in adults and adolescents aged 12–17. - Maintenance of healed erosive esophagitis in adults. - Short-term treatment of heartburn and other symptoms of gastroesophageal reflux disease (GERD) in adults and adolescents aged 12–17. - Reduction of NSAID-associated stomach ulcer risk in adults aged 60 or older and/or with a documented history of stomach ulcers. - Treatment of Helicobacter pylori infection, together with amoxicillin and clarithromycin, to reduce the risk of duodenal ulcers returning in adults. - Long-term treatment of conditions causing excessive stomach acid production, including Zollinger–Ellison syndrome, in adults.

Safety information

Side effects

Common side effects include headache, diarrhea, nausea, gas, abdominal pain, constipation and dry mouth. In children aged 1–17 years, common side effects include headache, diarrhea, abdominal pain, nausea and drowsiness. Serious side effects that warrant contacting a doctor include kidney inflammation, Clostridium difficile-associated diarrhea, severe skin reactions, and new or worsening lupus affecting the skin or other parts of the body. Stop taking Nexium and seek medical assessment at the first signs of a severe skin reaction or other allergic reaction. Long-term use may increase the risk of osteoporosis-related fractures of the hip, wrist or spine, vitamin B12 deficiency, and stomach polyps called fundic gland polyps. Low magnesium and related mineral disturbances have also been reported rarely with prolonged treatment. Contact your doctor if any of these problems develop.

When to call your doctor

- Seek medical attention immediately for a severe skin reaction or signs of an allergic reaction. - Seek urgent medical attention for severe or persistent diarrhea, which may be associated with a Clostridium difficile infection.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not take Nexium if you have a known allergy to esomeprazole, related medicines called substituted benzimidazoles, or any of its ingredients. Allergic reactions can include severe reactions, swelling, breathing difficulties, hives or kidney inflammation. Do not take Nexium with any medicine containing rilpivirine. Avoid taking Nexium with clopidogrel, St. John’s wort or rifampin. If Nexium is prescribed with amoxicillin and clarithromycin, the contraindications for both antibiotics must also be checked. Conditions and risks requiring caution include kidney inflammation, Clostridium difficile-associated diarrhoea, severe skin reactions, and new or worsening lupus. Stop Nexium and seek medical assessment if kidney inflammation, a severe skin reaction or lupus is suspected. Long-term use may increase the risk of osteoporosis-related fractures of the hip, wrist or spine, vitamin B12 deficiency, low magnesium and disturbances in mineral balance. The risk of fundic gland polyps increases with long-term use, particularly beyond one year. Tell your prescriber if you receive methotrexate, as Nexium may increase or prolong methotrexate levels and lead to toxicity. Temporary interruption of Nexium may be needed. Nexium can also interfere with chromogranin A blood tests used to investigate neuroendocrine tumours; the label advises stopping it at least 14 days before testing, under medical guidance. In adults, improvement in symptoms does not rule out stomach cancer, and further assessment may be needed. Use for symptomatic gastroesophageal reflux disease is not recommended in infants aged 1 month to under 1 year because effectiveness was not demonstrated.

Interactions

Nexium (esomeprazole) can interact with other medicines and St. John’s wort. Important interactions to discuss with your doctor include: • HIV medicines: Do not take Nexium with rilpivirine-containing products. Avoid use with nelfinavir. Atazanavir, saquinavir and ritonavir-containing products also need review because Nexium may affect their levels or they may affect Nexium levels. • Clopidogrel: Avoid taking it with Nexium, which can reduce its ability to prevent blood clots. • Warfarin: Nexium may increase its effect on blood clotting and the risk of serious bleeding. Blood-clotting tests need monitoring. • Methotrexate, especially when used at high doses: Nexium may increase and prolong methotrexate levels, increasing toxicity. Your doctor may temporarily stop Nexium. • Citalopram and cilostazol: Nexium can increase their levels. With citalopram, this can increase the risk of heart rhythm problems. Your prescriber may need to adjust treatment. • Digoxin and tacrolimus: Levels may increase and need blood-test monitoring. • Iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole and itraconazole: Nexium reduces stomach acidity and may reduce their absorption. Extra caution is needed in transplant patients taking mycophenolate mofetil. • Rifampin and St. John’s wort: Avoid taking these with Nexium because they can lower esomeprazole levels. • Voriconazole: This can increase esomeprazole levels. Treatment may need review, particularly in people with Zollinger-Ellison syndrome. If Nexium is prescribed with clarithromycin and amoxicillin, your doctor should also check their interactions with your other medicines. Some clarithromycin interactions can cause serious, potentially fatal heart rhythm problems. Tell the clinician arranging tests that you take Nexium. It can cause misleading results in chromogranin A testing for neuroendocrine tumors and secretin stimulation testing. Your clinician may need to stop Nexium before these tests. False-positive urine screening results for THC have also been reported with this type of medicine; a positive result may need confirmation using another method.

Using Nexium

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label NEXIUM (ESOMEPRAZOLE MAGNESIUM) CAPSULE, DELAYED RELEASE NEXIUM (ESOMEPRAZOLE MAGNESIUM) GRANULE, DELAYED RELEASE [ASTRAZENECA PHARMACEUTICALS LP] (DailyMed, retrieved 19 September 2026).

Patient information and references

Official and supporting information to read alongside advice from your prescriber or pharmacist.

Patient information leaflet (PDF)

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