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Malarone
Atovaquone & Proguanil
$336.00
62.25mg/25mg · 8 × 12 tablets · 3 months supply
BrandBranded medicine· By GSK
$112.00 per month
Strength
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Annual cost
$1260a year at this pack size
Prescription required
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62.25mg/25mg
250mg/100mg
About Malarone
Overview
Malarone tablets contain atovaquone and proguanil hydrochloride, two antimalarial medicines. It is used to prevent Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported, and to treat acute, uncomplicated malaria caused by this parasite. Its two active ingredients act as antimalarial agents.
What it treats
- Prevention of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. - Treatment of acute, uncomplicated Plasmodium falciparum malaria.
Safety information
Side effects
Common side effects vary by age and whether Malarone is used to prevent or treat malaria. When used for prevention, common effects in adults include diarrhea, dreams, mouth ulcers and headache. In children, they include stomach pain, headache, cough and vomiting. When used for treatment, common effects in adolescents and adults include stomach pain, nausea, vomiting, headache, diarrhea, weakness, loss of appetite and dizziness. In children, they include vomiting, itching and diarrhea. Serious side effects include liver problems and severe skin reactions. Increased liver blood test results, hepatitis and liver failure requiring a liver transplant have been reported during preventive use. Contact a doctor about suspected liver problems. Severe skin reactions, including Stevens–Johnson syndrome, can be life-threatening or fatal. Stop taking Malarone immediately and seek medical attention if signs of a severe skin reaction develop. Contact a doctor if vomiting or diarrhea is severe or persistent. These can reduce absorption of the medicine, and a different antimalarial treatment may be needed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Malarone if you have a known allergy to atovaquone, proguanil hydrochloride or any other ingredient. Do not use it to prevent P. falciparum malaria if you have severe kidney impairment (creatinine clearance below 30 mL/min). Diarrhoea or vomiting may reduce absorption. If you are vomiting during treatment, close monitoring of malaria parasites in the blood is needed. Severe or persistent diarrhoea or vomiting may require a different antimalarial medicine. Raised liver test results, hepatitis and liver failure requiring transplantation have been reported when Malarone is used for prevention. Severe skin reactions, including Stevens–Johnson syndrome, have also been reported and may be life-threatening or fatal. Stop Malarone immediately and seek medical care if signs of a severe skin reaction develop. Malarone alone may not prevent P. vivax malaria from returning in people infected with both P. falciparum and P. vivax. A different antimalarial is needed if P. falciparum infection returns after treatment or develops despite prevention. Malarone has not been evaluated for cerebral malaria or other severe, complicated malaria; severe malaria is not suitable for treatment with oral medicines.
Interactions
Tell your doctor if you take rifampin or rifabutin. These medicines lower atovaquone levels, so using them with Malarone is not recommended. Malarone may increase the blood-thinning effect of warfarin and other coumarin-based anticoagulants. Blood-clotting tests should be closely monitored when starting or stopping Malarone. Tetracycline may lower atovaquone levels. If taken with Malarone, the level of malaria parasites in the blood should be closely monitored.
Using Malarone
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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