Kapidex , Dexilant

Before taking this medicine

Do not take dexlansoprazole if you are allergic to any ingredient in the capsules or if you take any medicine containing rilpivirine. Allergic reactions can be severe. Important cautions include: • Kidney inflammation (acute tubulointerstitial nephritis): treatment should be stopped and the patient evaluated if this occurs. • Severe skin reactions or signs of an allergic reaction: stop treatment at the first signs and seek medical evaluation. • New or worsening lupus: stop treatment and seek specialist evaluation. • An increased risk of Clostridium difficile-associated diarrhea. • A possible increased risk of osteoporosis-related hip, wrist or spine fractures with long-term use. • Vitamin B12 deficiency, low magnesium and other mineral disturbances with prolonged use. • Fundic gland polyps, with risk increasing during long-term use, especially beyond one year. Treatment should be for the shortest duration needed. Improvement in symptoms does not rule out stomach cancer in adults; further assessment may be needed. Dexlansoprazole can also interfere with tests for neuroendocrine tumors. Tell your prescriber if you take methotrexate. Dexlansoprazole may increase or prolong methotrexate levels and cause toxicity; temporary interruption may be considered during high-dose methotrexate treatment. During pregnancy, animal data suggest a potential risk to fetal bone growth and development. Dexlansoprazole is not recommended for children under two years because of the risk of heart valve thickening. Based on lansoprazole data, it is not effective for symptomatic GERD in infants aged one month to under one year.