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Geodon
Ziprasidone
$528.00
40mg · 3 × 60 capsules · 3 months supply
BrandBranded medicine· By Pfizer
$176.00 per month
Strength
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Annual cost
$2112a year at this pack size
Prescription required
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FDA boxed warningIncreased mortality in elderly patients with dementia-related psychosis
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. GEODON is not approved for the treatment of patients with dementia-related psychosis.
About Geodon
Overview
Geodon capsules contain ziprasidone, an atypical antipsychotic medicine. They are used in adults to treat schizophrenia and, on their own, manic or mixed episodes associated with bipolar I disorder. They are also used alongside lithium or valproate for maintenance treatment of bipolar I disorder. Ziprasidone may work by blocking certain dopamine and serotonin receptors in the brain.
What it treats
- Schizophrenia in adults. - Acute manic or mixed episodes associated with bipolar I disorder in adults, used alone. - Maintenance treatment of bipolar I disorder in adults, used alongside lithium or valproate.
Safety information
Side effects
Common side effects of Geodon (ziprasidone) include sleepiness and respiratory tract infections in people treated for schizophrenia. In people treated for manic or mixed episodes of bipolar disorder, common side effects include sleepiness, movement problems, dizziness, restlessness, abnormal vision, weakness and vomiting. Contact a doctor immediately for serious reactions. These include changes in the heart’s electrical rhythm (QT prolongation), which can lead to sudden death; serotonin syndrome; neuroleptic malignant syndrome, a potentially fatal reaction; and severe, sometimes fatal skin reactions such as DRESS and Stevens–Johnson syndrome. Serotonin syndrome can occur with Geodon alone, and the risk increases when it is taken with other medicines that affect serotonin. An unexplained rash requires prompt medical attention; the label advises stopping Geodon if no cause is identified. Other serious effects include involuntary movements that may persist, seizures, reduced white blood cell counts, difficulty swallowing, a prolonged erection, and a drop in blood pressure on standing that may contribute to falls. Contact your doctor about these effects or about increased thirst, urination, hunger or weakness, which may indicate high blood sugar. Weight gain and changes in blood fats can also occur and require monitoring. Elderly patients with dementia-related psychosis have an increased risk of death and stroke. Patients at high risk of suicide need close supervision. Geodon may impair thinking and movement, so use caution when operating machinery.
FDA boxed warning
Increased mortality in elderly patients with dementia-related psychosis
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. GEODON is not approved for the treatment of patients with dementia-related psychosis.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not take Geodon if you have a known allergy to ziprasidone, a history of QT prolongation (a heart rhythm abnormality), a recent heart attack, or heart failure that is not adequately controlled. Do not take it with other medicines known to prolong the QT interval, with monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping an MAOI. Geodon should be avoided if you have a slow heartbeat, low blood potassium or magnesium, or congenital QT prolongation. It requires caution in people with heart or blood vessel disease, a history of stroke or other disease affecting blood flow to the brain, or seizures or conditions that increase seizure risk. Older people with dementia-related psychosis have an increased risk of stroke or transient ischaemic attack. Tell your prescriber if you have diabetes or risk factors for diabetes, a low white blood cell count, or a history of low white blood cells. Blood glucose, weight and, in some patients, blood counts need monitoring. Other medicines that affect serotonin increase the risk of serotonin syndrome, although it can also occur with Geodon alone. Serious risks include potentially fatal neuroleptic malignant syndrome and severe skin reactions, as well as involuntary movements. Geodon should be stopped if a severe skin reaction is suspected or a rash develops without an identified cause. People at high risk of suicide need close supervision. Use caution when operating machinery because Geodon may impair thinking and movement. Use during the third trimester of pregnancy may cause movement problems or withdrawal symptoms in the newborn.
Interactions
Geodon must not be taken with other medicines known to prolong the QT interval, a change in the heart’s electrical activity. Ask your doctor to check your other medicines for this interaction. Food can increase the amount of ziprasidone absorbed by up to two-fold. Discuss how to take your capsules in relation to food with your doctor.
Using Geodon
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label GEODON (ZIPRASIDONE HYDROCHLORIDE) CAPSULE GEODON (ZIPRASIDONE MESYLATE) INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION GEODON (ZIPRASIDONE) CAPSULE [ROERIG] (DailyMed, retrieved 19 September 2026).
Patient information and references
Official and supporting information to read alongside advice from your prescriber or pharmacist.
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