Eliquis, illustration of tablet form (not a photo of the actual pack)

Illustrative image.

Eliquis

Apixaban

Prescription required

$195.00

5mg · 3 × 60 tablets · 3 months supply

Generic

$65.00 per month

Brand or generic

Generic packs carry the same active ingredient at the same strength.

Strength

How long a supply?

1 month$65.00 a month
3 months$65.00 a month
6 months$65.00 a month
Supplied from Canada

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Annual cost

$780a year at this pack size

Prescription required

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2.5mg

5mg

FDA boxed warning(a) premature discontinuation of eliquis increases the risk of thrombotic events

(B) SPINAL/EPIDURAL HEMATOMA

(A) PREMATURE DISCONTINUATION OF ELIQUIS INCREASES THE RISK OF THROMBOTIC EVENTS

Premature discontinuation of any oral anticoagulant, including ELIQUIS, increases the risk of thrombotic events. If anticoagulation with ELIQUIS is discontinued for a reason other than pathological bleeding or completion of a course of therapy, consider coverage with another anticoagulant

Epidural or spinal hematomas may occur in patients treated with ELIQUIS who are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include:

use of indwelling epidural catheters

concomitant use of other drugs that affect hemostasis, such as nonsteroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, other anticoagulants

a history of traumatic or repeated epidural or spinal punctures

a history of spinal deformity or spinal surgery

optimal timing between the administration of ELIQUIS and neuraxial procedures is not known

Monitor patients frequently for signs and symptoms of neurological impairment. If neurological compromise is noted, urgent treatment is necessary

Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated

Read this with the rest of the clinical information

About Eliquis

Overview

Eliquis is a prescription medicine containing apixaban, used to reduce the risk of stroke and blood clots travelling through the body in adults with nonvalvular atrial fibrillation. It also treats deep vein thrombosis (DVT) and pulmonary embolism (PE) in adults and reduces the risk of these clots returning after initial treatment. It is also used to help prevent DVT, which can lead to PE, in adults after hip or knee replacement surgery. Apixaban blocks factor Xa, a protein involved in blood clotting, helping reduce clot formation.

What it treats

- Reducing the risk of stroke and blood clots travelling elsewhere in the body in adults with nonvalvular atrial fibrillation. - Preventing deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in adults after hip or knee replacement surgery. - Treating DVT and PE in adults, and reducing the risk of recurrence after initial treatment. - Treating venous thromboembolism (VTE) and reducing the risk of recurrence in children from birth, after at least 5 days of initial anticoagulant treatment.

Safety information

Side effects

The most common side effects in adults are related to bleeding. In children, the most common side effects are headache, vomiting and excessive menstrual bleeding. Eliquis can cause serious, potentially fatal bleeding. Report any signs or symptoms of blood loss to a doctor immediately or go to an emergency room. Taking Eliquis with aspirin, other medicines that prevent blood clots, NSAIDs or certain antidepressants can increase the risk of bleeding. Stopping Eliquis early without adequate alternative treatment to prevent blood clots increases the risk of blood clots, including stroke. Speak to your prescriber before stopping treatment.

FDA boxed warning

(a) premature discontinuation of eliquis increases the risk of thrombotic events

(B) SPINAL/EPIDURAL HEMATOMA

(A) PREMATURE DISCONTINUATION OF ELIQUIS INCREASES THE RISK OF THROMBOTIC EVENTS

Premature discontinuation of any oral anticoagulant, including ELIQUIS, increases the risk of thrombotic events. If anticoagulation with ELIQUIS is discontinued for a reason other than pathological bleeding or completion of a course of therapy, consider coverage with another anticoagulant

Epidural or spinal hematomas may occur in patients treated with ELIQUIS who are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include:

use of indwelling epidural catheters

concomitant use of other drugs that affect hemostasis, such as nonsteroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, other anticoagulants

a history of traumatic or repeated epidural or spinal punctures

a history of spinal deformity or spinal surgery

optimal timing between the administration of ELIQUIS and neuraxial procedures is not known

Monitor patients frequently for signs and symptoms of neurological impairment. If neurological compromise is noted, urgent treatment is necessary

Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated

A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.

When to call your doctor

- Seek medical attention immediately for signs of bleeding or blood loss, including excessive menstrual bleeding. - Seek emergency care for new nerve problems or paralysis after spinal or epidural anesthesia or a spinal puncture.

If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.

Before taking this medicine

Do not take Eliquis if you have active abnormal bleeding or have had a severe allergic reaction to Eliquis, such as anaphylaxis. Eliquis is not recommended during pregnancy or for people with an artificial heart valve, triple-positive antiphospholipid syndrome, or severe liver impairment. Do not breastfeed while taking Eliquis. Eliquis can cause serious, potentially fatal bleeding. Bleeding risk increases when it is taken with aspirin, other antiplatelet medicines, other anticoagulants, heparin, clot-dissolving medicines, SSRI or SNRI antidepressants, or nonsteroidal anti-inflammatory drugs (NSAIDs). Report signs of bleeding or blood loss immediately, or go to an emergency department. Do not stop Eliquis without medical advice. Stopping treatment early without adequate alternative anticoagulation increases the risk of blood clots. Your prescriber may need to arrange another anticoagulant.

Interactions

Ketoconazole, itraconazole and ritonavir can raise apixaban levels and increase bleeding risk. Your prescriber may need to adjust your treatment or avoid these combinations. Their use with Eliquis has not been studied in children. Rifampin, carbamazepine, phenytoin and the herbal supplement St. John’s wort can lower apixaban levels, increasing the risk of stroke and other blood clots. These combinations should be avoided. Aspirin, other antiplatelet medicines such as clopidogrel, blood thinners such as heparin, clot-dissolving medicines and regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) can increase bleeding risk with Eliquis. Tell your doctor if you take any of these medicines or supplements.

Using Eliquis

Dosing

Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.

Storage

Store below 25°C in a dry place, in the original pack, away from direct light and moisture. Do not keep it in a bathroom. Keep all medicines out of the sight and reach of children.

Clinical information on this page is summarised from the US FDA label ELIQUIS (APIXABAN) TABLET, FILM COATED [REMEDYREPACK INC.] (DailyMed, retrieved 19 September 2026).

Patient information and references

Official and supporting information to read alongside advice from your prescriber or pharmacist.

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