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Arixtra
Fondaparinux Sodium
$945.00
2.5mg · 9 × 10 syringes · 3 months supply
BrandBranded medicine· By Aspen
$315.00 per month
Strength
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Annual cost
$3885a year at this pack size
Prescription required
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2.5mg
7.5mg
FDA boxed warningSpinal/epidural hematomas
Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH), heparinoids, or fondaparinux sodium and are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include:
use of indwelling epidural catheters
concomitant use of other drugs that affect hemostasis, such as non-steroidal anti- inflammatory drugs (NSAIDs), platelet inhibitors, or other anticoagulants
a history of traumatic or repeated epidural or spinal puncture
a history of spinal deformity or spinal surgery
Optimal timing between the administration of ARIXTRA and neuraxial procedures is not known.
Monitor patients frequently for signs and symptoms of neurologic impairment. If neurologic compromise is noted, urgent treatment is necessary.
Consider the benefit and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis.
About Arixtra
Overview
Arixtra (fondaparinux sodium) is a prescription anticoagulant supplied in prefilled syringes for injection under the skin. It is used to prevent deep vein thrombosis (DVT) in adults undergoing hip fracture, hip replacement, knee replacement or abdominal surgery, and to treat DVT or acute pulmonary embolism in adults alongside warfarin. It also treats venous thromboembolism in children aged 1 year or older who weigh at least 10 kg. It works by helping a natural blood protein block Factor Xa, a clotting factor involved in forming blood clots.
What it treats
• Prevention of deep vein thrombosis (DVT) in adults undergoing hip fracture surgery, hip replacement, knee replacement or abdominal surgery, including extended prevention after hip fracture surgery. • Treatment of DVT or acute pulmonary embolism (PE) in adults, used together with warfarin sodium. • Treatment of venous thromboembolism (VTE) in children aged 1 year or older who weigh at least 10 kg.
Safety information
Side effects
Bleeding complications are the most serious side effects of Arixtra. Bleeding around the spinal cord (spinal or epidural hematoma) can cause long-term or permanent paralysis. Low platelet counts (thrombocytopenia) can also occur. Contact a doctor promptly if you experience bleeding or an allergic reaction. The syringe needle guard contains dry natural rubber, which may cause allergic reactions in people sensitive to latex. Bleeding risk is higher in people with reduced kidney function, adults weighing less than 50 kg, and people with other risk factors for bleeding.
FDA boxed warning
Spinal/epidural hematomas
Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH), heparinoids, or fondaparinux sodium and are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include:
use of indwelling epidural catheters
concomitant use of other drugs that affect hemostasis, such as non-steroidal anti- inflammatory drugs (NSAIDs), platelet inhibitors, or other anticoagulants
a history of traumatic or repeated epidural or spinal puncture
a history of spinal deformity or spinal surgery
Optimal timing between the administration of ARIXTRA and neuraxial procedures is not known.
Monitor patients frequently for signs and symptoms of neurologic impairment. If neurologic compromise is noted, urgent treatment is necessary.
Consider the benefit and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis.
A boxed warning is the strongest warning the US Food and Drug Administration requires on a medicine label. Text is taken from the official label, with internal section references removed.
When to call your doctor
If symptoms are severe or getting worse quickly, seek emergency care rather than waiting.
Before taking this medicine
Do not use Arixtra if you have severe kidney impairment (creatinine clearance below 30 mL/min), active major bleeding, bacterial endocarditis (a bacterial infection of the heart’s inner lining), or a history of a serious allergic reaction to Arixtra. It must also not be used if you have a low platelet count associated with a positive laboratory test for anti-platelet antibodies in the presence of fondaparinux sodium. Adults weighing less than 50 kg must not use Arixtra to prevent blood clots in veins. Extra caution is needed if you have risk factors for bleeding, reduced kidney or liver function, or weigh less than 50 kg. Older people require caution because they are more likely to have reduced kidney function. Bleeding around the spine or in the epidural space can occur and may cause long-term or permanent paralysis. Arixtra can cause a low platelet count. Periodic blood counts, including platelet counts, kidney function tests and stool tests for hidden blood are recommended. The needle guard contains dry natural rubber, which may cause allergic reactions in people sensitive to latex.
Interactions
Tell your doctor if you take other medicines that increase bleeding risk, including anticoagulants such as warfarin, platelet inhibitors such as aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) such as piroxicam. Your doctor should review whether these medicines need to be stopped before you start Arixtra. If they are essential and must be used together, you will need close monitoring for bleeding.
Using Arixtra
Dosing
Dosing is set by your prescriber. Each health care professional may prescribe medication differently according to a patient's medical history and condition, so follow the directions on your prescription label and speak to your doctor or pharmacist before changing anything.
Storage
Store in the original carton to protect it from light. Check the pack for whether it must be refrigerated before first use. Keep all medicines out of the sight and reach of children.
Clinical information on this page is summarised from the US FDA label ARIXTRA (FONDAPARINUX SODIUM) INJECTION, SOLUTION [MYLAN INSTITUTIONAL LLC] (DailyMed, retrieved 19 September 2026).
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