Aciphex

Before taking this medicine

Do not take Aciphex if you are allergic to rabeprazole, substituted benzimidazoles or any ingredient in the tablets, or if you take a medicine containing rilpivirine. The tablet strength covered by this label is not appropriate for children under 12 years. Tell your prescriber if you take warfarin or methotrexate. Warfarin requires monitoring of blood-clotting tests. Aciphex may increase methotrexate levels and toxicity; your prescriber may temporarily stop Aciphex during high-dose methotrexate treatment. If Aciphex is prescribed with clarithromycin and amoxicillin, the contraindications for both antibiotics also apply. Aciphex can cause kidney inflammation, serious allergic reactions, severe skin reactions, and new or worsening lupus. Stop treatment and seek medical assessment if a serious allergic or skin reaction is suspected. Suspected kidney inflammation or lupus also requires stopping treatment and medical evaluation. Other cautions include an increased risk of Clostridium difficile-associated diarrhea, osteoporosis-related fractures with long-term treatment, vitamin B12 deficiency with prolonged use, and rarely low magnesium or other mineral disturbances. Long-term use also increases the risk of growths in the stomach lining called fundic gland polyps, especially beyond one year. Improvement in symptoms does not rule out stomach cancer in adults; further testing or follow-up may still be needed.